Filmography63 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2027 | Robot Chicken: The MovieMovie | Various (voice) | 56 |
| 2022 | The Bad GuysMovie | Police Chief Misty Luggins (voice) | 51 |
| 2021 | Resident AlienSeries | Carlyn | 50 |
| 2021 | Celebrity Wheel of FortuneSeries | Self - Contestant | 50 |
| 2021 | ExtinctMovie | Mali (voice) | 50 |
| 2020 | Awkwafina Is Nora from QueensSeries | Wilma (voice) | 49 |
| 2019 | The Kelly Clarkson ShowSeries | Self | 48 |
| 2019 | Las que faltabanSeries | Invitada | 48 |
| 2017 | The Marvelous Mrs. MaiselSeries | Susie Myerson | 46 |
| 2016 | The Angry Birds MovieMovie | Sophie Bird / Peggy Bird (voice) | 45 |
| 2016 | Gilmore Girls: A Year in the LifeSeries | Drella | 45 |
| 2016 | BordertownSeries | Becky Buckwald | 45 |
| 2016 | Man Rots from the HeadMovie | Gladys | 45 |
| 2015 | The Late Show with Stephen ColbertSeries | Self | 44 |
| 2015 | Life in PiecesSeries | Linette | 44 |
| 2015 | Robot Chicken DC Comics Special III: Magical FriendshipMovie | Wonder Woman (voice) | 44 |
| 2015 | Love the CoopersMovie | Angie Cooper | 44 |
| 2015 | TV's Funniest Animated Stars: A Paley Center for Media SpecialMovie | Self | 44 |
| 2014 | Late Night with Seth MeyersSeries | Self | 43 |
| 2014 | A Million Ways to Die in the WestMovie | Millie | 43 |
| 2014 | DeliriumSeries | Lois Griffin (archive footage) | 43 |
| 2014 | Robot Chicken DC Comics Special II: Villains in ParadiseMovie | Wonder Woman (voice) | 43 |
| 2013 | Getting OnSeries | Dawn Forchette | 42 |
| 2013 | Masters of SexSeries | Loretta | 42 |
| 2012 | TedMovie | John's Mom | 41 |
| 2012 | Robot Chicken: DC Comics SpecialMovie | Wonder Woman / Giganta / Woman (voice) | 41 |
| 2012 | ParaNormanMovie | Mrs. Henscher (voice) | 41 |
| 2011 | ShamelessSeries | Lou Deckner | 40 |
| 2011 | WorkaholicsSeries | Colleen Walker | 40 |
| 2011 | For Christ's SakeMovie | Mrs. Marcus | 40 |
| 2010 | Hot in ClevelandSeries | Preshi | 39 |
| 2010 | KillersMovie | Mrs. Baily | 39 |
| 2010 | Family Guy Presents: It's a Trap!Movie | Lois Griffin as Princess Leia / Sy Snootles / Asian Woman / ET Announcer / Hot Girl's Mother (voice) | 39 |
| 2010 | Dinner for SchmucksMovie | Red Hair Woman (uncredited) | 39 |
| 2009 | The Cleveland ShowSeries | — | 38 |
| 2009 | Family Guy Presents: Something, Something, Something, Dark SideMovie | Lois Griffin as Princess Leia / OnStar Voiceover / Empire Member's Wife / Robot Wife (voice) | 38 |
| 2009 | Family Guy Presents: Stewie Kills Lois and Lois Kills StewieMovie | Lois Griffin (voice) | 38 |
| 2008 | Seth MacFarlane's Cavalcade of Cartoon ComedySeries | Various Characters (voice) | 37 |
| 2007 | Family Guy Presents: Blue HarvestMovie | Lois Griffin as Princess Leia / Barbara Pewterschmidt as Aunt Beru (voice) | 36 |
| 2007 | The Thick of ItMovie | Hope Mueller | 36 |
| 2006 | Talkshow with Spike FerestenSeries | — | 35 |
| 2006 | Little ManMovie | Janet | 35 |
| 2005 | American Dad!Series | — | 34 |
| 2005 | Stewie Griffin: The Untold StoryMovie | Lois Griffin / Various Characters (voice) | 34 |
| 2005 | Kicking & ScreamingMovie | Obnoxious Hummer Lady (uncredited) | 34 |
| 2005 | Good Night, and Good Luck.Movie | Natalie | 34 |
| 2004 | CatwomanMovie | Sally | 33 |
| 2004 | Celebrity BlackjackSeries | — | 33 |
| 2003 | Jimmy Kimmel Live!Series | Self | 32 |
| 2003 | Bad SantaMovie | Milwaukee Mom with Photo | 32 |
| 2002 | ShowtimeMovie | Casting Director | 31 |
| 2002 | DawgMovie | Darcy Smits | 31 |
| 2002 | Never Mind the BuzzcocksSeries | Self | 31 |
| 2001 | A Very Special Family Guy Freakin' ChristmasMovie | Lois Griffin / Female Hipster / Julie / Grandma (voice) | 30 |
| 2001 | Gary & MikeSeries | Maya (voice) | 30 |
| 2000 | TitusSeries | Nicky | 29 |
| 2000 | Gilmore GirlsSeries | Drella | 29 |
| 1999 | Family GuySeries | Lois Griffin / Tricia Takanawa / Loretta Brown / Barbara Pewterschmidt (voice) | 28 |
| 1996 | Big Bad BeetleBorgsSeries | Cataclaws (voice) | 25 |
| 1995 | MADtvSeries | Various | 24 |
| 1994 | FriendsSeries | Bitter Woman on Stage | 23 |
| 1993 | FrasierSeries | Evelyn | 22 |
| 1993 | Power RangersSeries | Queen Machina (voice) | 22 |