Filmography34 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2021 | INVINCIBLESeries | April (voice) | 57 |
| 2021 | Indiana Jones: The Search for the Lost Golden AgeMovie | Self - Actress (archive footage) | 57 |
| 2017 | FEUDSeries | Lee Radziwill | 53 |
| 2015 | SupergirlSeries | Cat Grant | 51 |
| 2013 | Full CircleSeries | Ellen Kelly-O'Rourke | 49 |
| 2012 | FOX 25th Anniversary SpecialMovie | Self | 48 |
| 2011 | Web TherapySeries | April Keating | 47 |
| 2008 | The Penguins of MadagascarSeries | Doris (voice) | 44 |
| 2008 | Web TherapySeries | April Keating | 44 |
| 2006 | Brothers and SistersSeries | Kitty Walker | 42 |
| 2005 | Robot ChickenSeries | Dr. Ryan Stone / Smurfette (voice) | 41 |
| 2005 | FragileMovie | Amy Nicholls | 41 |
| 2005 | The Reichen ShowSeries | Self | 41 |
| 2004 | TV RevolutionSeries | — | 40 |
| 2004 | The Last ShotMovie | Valerie Weston | 40 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 39 |
| 2000 | Things You Can Tell Just by Looking at HerMovie | Christine Taylor (segments "Goodnight Lilly, Goodnight Christine" and "This is Dr. Keener") | 36 |
| 1999 | Pictures of Baby Jane DoeMovie | Jane | 35 |
| 1999 | A Midsummer Night's DreamMovie | Helena | 35 |
| 1997 | Ally McBealSeries | Ally McBeal | 33 |
| 1997 | The PracticeSeries | Ally McBeal | 33 |
| 1997 | Telling Lies in AmericaMovie | Diney Majeski | 33 |
| 1996 | Milk & MoneyMovie | Christine | 32 |
| 1995 | Happily Ever After: Fairy Tales for Every ChildSeries | Vanna Van (voice) | 31 |
| 1995 | MADtvSeries | Self | 31 |
| 1994 | Quiz ShowMovie | Barnard Girl | 30 |
| 1994 | Getting InMovie | Amanda Morel | 30 |
| 1993 | Intimate PortraitSeries | Self | 29 |
| 1993 | Naked in New YorkMovie | Acting Student | 29 |
| 1992 | The Tonight Show with Jay LenoSeries | Self | 28 |
| 1991 | DarrowMovie | Lillian Anderson | 27 |
| 1988 | LIVE with Kelly and MarkSeries | — | 24 |
| 1975 | Saturday Night LiveSeries | Self - Host | 11 |
| 1944 | Golden Globe AwardsSeries | Self - Nominee | — |