Filmography44 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2014 | Over the Garden WallSeries | Enoch / Additional Voices (voice) | 58 |
| 2014 | Twin Peaks: The Missing PiecesMovie | Special Agent Chester Desmond | 58 |
| 2012 | Chris Isaak: Live in Concert and Greatest Hits Live ConcertMovie | Self – Vocals | 56 |
| 2010 | Hot in ClevelandSeries | Chase Jackson | 54 |
| 2009 | O Melhor do Flash Back - 92 Clipes Para RecordarMovie | Self (archive footage) | 53 |
| 2008 | The InformersMovie | Les Price | 52 |
| 2008 | Elvis | Viva Las VegasMovie | Self | 52 |
| 2007 | Jerry Lee Lewis: Last Man Standing, LiveMovie | Self | 51 |
| 2006 | Best of Chris IsaakMovie | Self (archive footage) | 50 |
| 2005 | American Dad!Series | (voice) | 49 |
| 2005 | The X FactorSeries | Self - Judge | 49 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 47 |
| 2003 | Jimmy Kimmel Live!Series | Self - Musical Guest | 47 |
| 2003 | SoundStage - Chris Isaak & Raul MaloMovie | Self | 47 |
| 2002 | American DreamsSeries | Roy Orbison | 46 |
| 2001 | Star AcademySeries | Self | 45 |
| 2001 | The Chris Isaak ShowSeries | Chris Isaak | 45 |
| 2000 | EdSeries | Jamie Decker | 44 |
| 2000 | MTV Unplugged: Classic MomentsMovie | Self | 44 |
| 1999 | The Late Late Show with Craig KilbornSeries | Self | 43 |
| 1999 | In Dreams: The Roy Orbison StoryMovie | Self | 43 |
| 1999 | Blue Ridge FallMovie | Emerson Cotswold | 43 |
| 1999 | A Tribute to Johnny CashMovie | Self - Performer | 43 |
| 1998 | From the Earth to the MoonSeries | Ed White | 42 |
| 1996 | That Thing You Do!Movie | Uncle Bob | 40 |
| 1996 | The Rosie O'Donnell ShowSeries | Self | 40 |
| 1995 | MADtvSeries | Self | 39 |
| 1994 | FriendsSeries | Rob Donnen | 38 |
| 1993 | Little BuddhaMovie | Dean Conrad | 37 |
| 1993 | Late Night with Conan O'BrienSeries | Self - Musical Guest | 37 |
| 1992 | The Larry Sanders ShowSeries | Chris Isaak | 36 |
| 1992 | The Tonight Show with Jay LenoSeries | Self | 36 |
| 1992 | Melrose PlaceSeries | Chris Isaak | 36 |
| 1992 | Twin Peaks: Fire Walk with MeMovie | Special Agent Chester Desmond | 36 |
| 1991 | The Silence of the LambsMovie | SWAT Commander | 35 |
| 1990 | The WordSeries | — | 34 |
| 1989 | MTV UnpluggedSeries | Self | 33 |
| 1988 | Married to the MobMovie | 'The Clown' | 32 |
| 1988 | This MorningSeries | Self | 32 |
| 1988 | Let's Get LostMovie | Self | 32 |
| 1987 | Le monde est à vousSeries | Self | 31 |
| 1975 | Saturday Night LiveSeries | Self - Musical Guest | 19 |
| 1962 | The Tonight Show Starring Johnny CarsonSeries | Self | 6 |
| 0 | Target Video: Underground Forces Vol. 3Movie | Self | — |