| 2025 | Spinal Tap II: The End ContinuesMovie | Nigel Tufnel | 77 |
| 2022 | Jamie Lee Curtis: Hollywood Call of FreedomMovie | Self (archive footage) | 74 |
| 2015 | Drunk Stoned Brilliant DeadMovie | Self - Actor | 67 |
| 2015 | Misery Loves ComedyMovie | Self | 67 |
| 2009 | The Invention of LyingMovie | Nathan Goldfrappe | 61 |
| 2009 | Night at the Museum: Battle of the SmithsonianMovie | Ivan the Terrible | 61 |
| 2009 | Unwigged & Unplugged: An Evening with Christopher Guest, Michael McKean and Harry ShearerMovie | Self | 61 |
| 2007 | Mr. Warmth: The Don Rickles ProjectMovie | Self | 59 |
| 2006 | For Your ConsiderationMovie | Jay Berman | 58 |
| 2005 | Mrs. Henderson PresentsMovie | Lord Cromer | 57 |
| 2005 | Saturday Night Live in the '80s: Lost and FoundMovie | Self | 57 |
| 2003 | Jimmy Kimmel Live!Series | Nigel Tufnel | 55 |
| 2003 | A Mighty WindMovie | Alan Barrows | 55 |
| 2001 | As You Wish: The Story of 'The Princess Bride'Movie | Self | 53 |
| 2000 | Best in ShowMovie | Harlan Pepper | 52 |
| 1999 | SpongeBob SquarePantsSeries | Stanley S. Squarepants (voice) | 51 |
| 1999 | The Early ShowSeries | Nigel Tufnel | 51 |
| 1999 | Where Are They Now?Series | Self | 51 |
| 1999 | DilbertSeries | The Dupey (voice) | 51 |
| 1998 | Small SoldiersMovie | Slamfist / Scratch-It (voice) | 50 |
| 1997 | The ViewSeries | Self | 49 |
| 1997 | Waiting for GuffmanMovie | Corky St. Clair | 49 |
| 1996 | E! True Hollywood StorySeries | — | 48 |
| 1993 | AnimaniacsSeries | Umlatt (voice) | 45 |
| 1992 | A Few Good MenMovie | Dr. Stone | 44 |
| 1992 | Metallica: A Year and a Half in the Life of MetallicaMovie | Nigel Tufnel | 44 |
| 1992 | A Spinal Tap Reunion: The 25th Anniversary London Sell-OutMovie | Nigel Tufnel / Alan Barrows | 44 |
| 1991 | Amnesty International's Big 30Movie | Nigel Tufnel | 43 |
| 1989 | The SimpsonsSeries | Nigel Tufnel (voice) | 41 |
| 1989 | Saturday Night Live: 15th AnniversaryMovie | Self | 41 |
| 1989 | I, Martin Short, Goes HollywoodMovie | Antoninus DiMentabella | 41 |
| 1988 | Sticky FingersMovie | Sam | 40 |
| 1987 | The Princess BrideMovie | Count Rugen | 39 |
| 1987 | Beyond TherapyMovie | Bob | 39 |
| 1986 | Little Shop of HorrorsMovie | The First Customer | 38 |
| 1985 | Martin Short: Concert for the North AmericasMovie | Rajiv Vindaloo | 37 |
| 1983 | Close TiesMovie | Ira | 35 |
| 1982 | St. ElsewhereSeries | H.J. Cummings | 34 |
| 1982 | A Piano for Mrs. CiminoMovie | Philip Ryan | 34 |
| 1982 | The Million Dollar InfieldMovie | Bucky Frische | 34 |
| 1981 | HeartbeepsMovie | Calvin | 33 |
| 1981 | Spinal Tap: The Final TourMovie | Nigel Tufnel | 33 |
| 1980 | The Long RidersMovie | Charlie Ford | 32 |
| 1980 | HaywireMovie | The TV Director | 32 |
| 1979 | The Last WordMovie | Roger | 31 |
| 1979 | Blind AmbitionSeries | Jeb Stuart Magruder | 31 |
| 1979 | CBS News Sunday MorningSeries | Self | 31 |
| 1979 | The Chevy Chase National Humor TestMovie | — | 31 |
| 1979 | The T.V. ShowMovie | — | 31 |
| 1978 | How to Survive the '70s and Maybe Even Bump Into HappinessMovie | — | 30 |
| 1978 | GirlfriendsMovie | Eric | 30 |
| 1978 | The Billion Dollar BubbleMovie | Al Green | 30 |
| 1977 | It Happened One ChristmasMovie | Harry Bailey | 29 |
| 1976 | Laverne & ShirleySeries | — | 28 |
| 1975 | Saturday Night LiveSeries | Self - Various Characters | 27 |
| 1975 | The FortuneMovie | Boy Lover | 27 |
| 1974 | Death WishMovie | Patrolman Reilly | 26 |
| 1973 | LemmingsMovie | Various | 25 |
| 1972 | The Hot RockMovie | Policeman | 24 |
| 1971 | The HospitalMovie | Resident (uncredited) | 23 |
| 1971 | All in the FamilySeries | Jim | 23 |
