Filmography88 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | Scream 7Movie | Gale Weathers | 62 |
| 2025 | Matthew Perry: A Hollywood TragedyMovie | Self - Actor & Co-Star (archive footage) | 61 |
| 2024 | The Charlie Puth ShowSeries | Courteney Cox | 60 |
| 2023 | Scream VIMovie | Gale Weathers | 59 |
| 2022 | ScreamMovie | Gale Weathers | 58 |
| 2022 | Shining ValeSeries | Patricia 'Pat' Phelps | 58 |
| 2021 | Friends: The ReunionMovie | Self | 57 |
| 2020 | The Drew Barrymore ShowSeries | Self | 56 |
| 2020 | You Cannot Kill David ArquetteMovie | Self | 56 |
| 2020 | All in Washington: A Concert for COVID-19 ReliefMovie | Self | 56 |
| 2019 | The Masked SingerSeries | Special Message (via video) | 55 |
| 2018 | 25 Words or LessSeries | Self | 54 |
| 2017 | The Gong ShowSeries | Self - Judge | 53 |
| 2016 | Mothers and DaughtersMovie | Beth | 52 |
| 2016 | Must See TV: An All Star Tribute to James BurrowsMovie | Self | 52 |
| 2015 | The Late Late Show with James CordenSeries | Self | 51 |
| 2015 | Hot OnesSeries | Self | 51 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self - Guest | 50 |
| 2014 | Variety Studio: Actors on ActorsSeries | Self | 50 |
| 2014 | Late Night with Seth MeyersSeries | Self | 50 |
| 2014 | Off Camera with Sam JonesSeries | Self | 50 |
| 2014 | Celebrity Name GameSeries | Self | 50 |
| 2014 | Running Wild with Bear GryllsSeries | Self | 50 |
| 2012 | Vanilla Ice ArchiveMovie | Self (archive footage) | 48 |
| 2011 | ShamelessSeries | Jen Wagner | 47 |
| 2011 | Scream 4Movie | Gale Weathers | 47 |
| 2011 | Web TherapySeries | Serena Duvall | 47 |
| 2011 | The Making of 'Scream 4'Movie | Self | 47 |
| 2010 | Who Do You Think You Are?Series | Self | 46 |
| 2009 | Cougar TownSeries | Jules Cobb | 45 |
| 2009 | Modern FamilySeries | Courteney Cox | 45 |
| 2008 | Bedtime StoriesMovie | Wendy | 44 |
| 2008 | Web TherapySeries | Serena DuVall | 44 |
| 2008 | Alien Love TriangleMovie | Alice | 44 |
| 2007 | DirtSeries | Lucy Spiller | 43 |
| 2007 | The Graham Norton ShowSeries | Self | 43 |
| 2007 | Alexis Arquette: She's My BrotherMovie | Self | 43 |
| 2006 | BarnyardMovie | Daisy (voice) | 42 |
| 2006 | The TripperMovie | Cynthia | 42 |
| 2006 | ZoomMovie | Marsha Holloway | 42 |
| 2005 | The Longest YardMovie | Lena | 41 |
| 2005 | The Reichen ShowSeries | Self | 41 |
| 2004 | NovemberMovie | Sophie Jacobs | 40 |
| 2003 | Jimmy Kimmel Live!Series | Self | 39 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 39 |
| 2003 | Celebrities UncensoredSeries | Self | 39 |
| 2002 | NBC 75th Anniversary SpecialMovie | Self | 38 |
| 2001 | ScrubsSeries | Dr. Maddox | 37 |
| 2001 | 3000 Miles to GracelandMovie | Cybil Waingrow | 37 |
| 2001 | The Shrink Is InMovie | Samantha Crumb | 37 |
| 2001 | Bruce Springsteen: The Complete Video Anthology 1978-2000Movie | Bruce's Fan (segment "Dancing in the Dark") | 37 |
| 2001 | Get Well SoonMovie | Lily Charles | 37 |
| 1999 | The RunnerMovie | Karina | 35 |
| 1999 | SNL: The Best of Adam SandlerMovie | Self / Guest Host (archive footage) (uncredited) | 35 |
| 1997 | CommandmentsMovie | Rachel Luce | 33 |
| 1997 | Scream 2Movie | Gale Weathers | 33 |
| 1996 | ScreamMovie | Gale Weathers | 32 |
| 1996 | E! True Hollywood StorySeries | Self (archive footage) | 32 |
| 1996 | The Rosie O'Donnell ShowSeries | Self - Guest | 32 |
| 1995 | Happily Ever After: Fairy Tales for Every ChildSeries | Emerald Salt Pork (voice) | 31 |
| 1995 | Sketch Artist II: Hands That SeeMovie | Emmy | 31 |
| 1994 | FriendsSeries | Monica Geller | 30 |
| 1994 | Ace Ventura: Pet DetectiveMovie | Melissa Robinson | 30 |
| 1993 | Late Show with David LettermanSeries | Self - Guest | 29 |
| 1993 | Intimate PortraitSeries | Self | 29 |
| 1993 | The Trouble with LarrySeries | Gabriella Easden | 29 |
| 1992 | The Larry Sanders ShowSeries | Courteney Cox | 28 |
| 1992 | MTV Movie & TV AwardsSeries | — | 28 |
| 1992 | The Tonight Show with Jay LenoSeries | Self | 28 |
| 1992 | The Opposite Sex and How to Live with ThemMovie | Carrie Davenport | 28 |
| 1992 | Battling for BabyMovie | Katherine | 28 |
| 1991 | Blue DesertMovie | Lisa Roberts | 27 |
| 1990 | Dream OnSeries | Alisha | 26 |
| 1990 | Mr. DestinyMovie | Jewel Jagger | 26 |
| 1990 | Curiosity KillsMovie | Gwen | 26 |
| 1989 | SeinfeldSeries | Meryl | 25 |
| 1989 | Judith Krantz's Till We Meet AgainSeries | Marie-Frederique 'Freddy' de Lancel | 25 |
| 1988 | LIVE with Kelly and MarkSeries | Self - Guest | 24 |
| 1988 | I'll Be Home for ChristmasMovie | Nora Bundy | 24 |
| 1987 | Masters of the UniverseMovie | Julie Winston | 23 |
| 1987 | Down TwistedMovie | Tarah | 23 |
| 1987 | DispatchesSeries | — | 23 |
| 1985 | Misfits of ScienceSeries | Gloria Dinallo | 21 |
| 1985 | Misfits of ScienceMovie | Gloria Dinallo | 21 |
| 1984 | Murder, She WroteSeries | Carol Bannister | 20 |
| 1982 | Family TiesSeries | Lauren Miller | 18 |
| 1981 | Entertainment TonightSeries | Self | 17 |
| 1975 | Saturday Night LiveSeries | Self - Host | 11 |