| 2026 | Each Day in a Moment: 2025Movie | Self (archive footage) (uncredited) | 74 |
| 2026 | Expectations feat. Chappell RoanMovie | Johnny Johnson | 74 |
| 2025 | The TwitsMovie | Gordon Sniffles (voice) | 73 |
| 2025 | SNL50: The Homecoming ConcertMovie | Self | 73 |
| 2025 | Ladies & Gentlemen... 50 Years of SNL MusicMovie | Self | 73 |
| 2025 | We Want the Funk!Movie | Self | 73 |
| 2025 | Breakdown: 1975Movie | Self (archive footage) | 73 |
| 2024 | EnoMovie | Self | 72 |
| 2020 | Stars in the HouseSeries | Self - Winner | 68 |
| 2020 | BREAK IT ALL: The History of Rock in Latin AmericaSeries | Self | 68 |
| 2020 | David Byrne's American UtopiaMovie | Self - Lead Singer & Performer | 68 |
| 2019 | Museum TownMovie | Self | 67 |
| 2018 | Real LifeMovie | Narrator / Self | 66 |
| 2016 | WIRED's Autocomplete InterviewsSeries | Self - Guest | 64 |
| 2016 | Michael Jackson's Journey from Motown to Off the WallMovie | Self | 64 |
| 2016 | Contemporary ColorMovie | — | 64 |
| 2015 | The Late Show with Stephen ColbertSeries | Self - Musical Guest | 63 |
| 2015 | StarTalk with Neil deGrasse TysonSeries | Self | 63 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self | 62 |
| 2014 | Late Night with Seth MeyersSeries | Self - Guest | 62 |
| 2014 | Lennon or McCartneyMovie | Self | 62 |
| 2013 | Fathers and Songs: Music for Father's DayMovie | Self (archive footage) | 61 |
| 2012 | Paul Simon: Under African SkiesMovie | Self | 60 |
| 2011 | The Jonathan Ross ShowSeries | Self - Guest | 59 |
| 2011 | This Must Be the PlaceMovie | David Byrne | 59 |
| 2011 | Talking Heads - ChronologyMovie | — | 59 |
| 2011 | Ride, Rise, RoarMovie | Self | 59 |
| 2009 | Burning Down the House: The Story of CBGBMovie | Self | 57 |
| 2009 | Wandering HeartMovie | Self | 57 |
| 2009 | Beyond IpanemaMovie | Self | 57 |
| 2009 | Tom Zé: Liberated AstronautMovie | — | 57 |
| 2008 | Celia: The QueenMovie | Self | 56 |
| 2008 | Wild Combination: A Portrait of Arthur RussellMovie | Self (archive footage) | 56 |
| 2006 | Fabricating Tom ZéMovie | Self | 54 |
| 2003 | Real Time with Bill MaherSeries | Self | 51 |
| 2003 | Jimmy Kimmel Live!Series | Self - Musical Guest | 51 |
| 2003 | Lubbock LightsMovie | Self | 51 |
| 2000 | The Art of AmáliaMovie | Introduction (English version) | 48 |
| 1998 | Lulu on the BridgeMovie | "Laughing Man" Escort | 46 |
| 1998 | Lou Reed: Rock and Roll HeartMovie | Self | 46 |
| 1997 | Sessions at West 54thSeries | Self - Host | 45 |
| 1995 | Dancing BarefootMovie | Self | 43 |
| 1994 | Space Ghost Coast to CoastSeries | Self | 42 |
| 1993 | Late Show with David LettermanSeries | Self - Musical Guest | 41 |
| 1991 | Until the End of the WorldMovie | Self | 39 |
| 1990 | Red Hot + Blue: A Tribute to Cole PorterMovie | Self | 38 |
| 1989 | The SimpsonsSeries | David Byrne (voice) | 37 |
| 1989 | DecadeMovie | Self | 37 |
| 1988 | Checking OutMovie | Bartender | 36 |
| 1988 | Talking Heads: Storytelling GiantMovie | Self | 36 |
| 1986 | True StoriesMovie | Narrator / Lip-Syncher | 34 |
| 1986 | The Kitchen Presents: Two Moon JulyMovie | — | 34 |
| 1986 | Dead End KidsMovie | Minister | 34 |
| 1985 | The Max Headroom ShowSeries | Self | 33 |
| 1984 | Stop Making SenseMovie | Self - Vocals, Guitar | 32 |
| 1984 | Talking Heads: The Name of this Programme is Once In A LifetimeMovie | Self | 32 |
| 1982 | Talking Heads: Live at Montreux Jazz FestivalMovie | — | 30 |
| 1981 | Talking Heads: Rock Pop in ConcertMovie | — | 29 |
| 1980 | Talking Heads: Live in RomeMovie | Self - Vocals, guitar | 28 |
| 1980 | Talking Heads: Capitol TheatreMovie | Self - Lead Vocals, Guitar | 28 |
| 1975 | Saturday Night LiveSeries | Self - Musical Guest | 23 |
| 1975 | Austin City LimitsSeries | Self | 23 |
| 1968 | 60 MinutesSeries | Self | 16 |
| 1962 | The Tonight Show Starring Johnny CarsonSeries | Self | 10 |
| 1953 | The OscarsSeries | Self | 1 |
| 0 | Talking Heads: 77Movie | — | — |
