| 2026 | OutcomeMovie | Drew Barrymore | 51 |
| 2025 | Hollywood SquaresSeries | Self | 50 |
| 2024 | Smile 2Movie | Drew Barrymore | 49 |
| 2024 | Jim Henson Idea ManMovie | Self (archive footage) | 49 |
| 2024 | Dolly Parton's Pet GalaMovie | — | 49 |
| 2023 | Pretty Baby: Brooke ShieldsSeries | Self | 48 |
| 2022 | ScreamMovie | Principal (voice) (uncredited) | 47 |
| 2022 | Mariah Carey: Merry Christmas to All!Movie | Self | 47 |
| 2022 | Celebrating Betty White: America's Golden GirlMovie | Self | 47 |
| 2021 | And Just Like That…Series | Drew Barrymore | 46 |
| 2021 | A Castle for ChristmasMovie | Self | 46 |
| 2021 | 2021 Rock & Roll Hall of Fame Induction CeremonyMovie | Self | 46 |
| 2021 | When Ruby Wax Met...Series | Self (archive footage) | 46 |
| 2021 | The D'Amelio ShowSeries | Self | 46 |
| 2021 | Who Are You, Charlie Brown?Movie | Self - Actor, Producer | 46 |
| 2021 | Madame X Presents: Madame Xtra Q&AMovie | Self | 46 |
| 2020 | The Drew Barrymore ShowSeries | Self - Host | 45 |
| 2020 | The Stand InMovie | Paula / Candy | 45 |
| 2020 | The Not-Too-Late Show with ElmoSeries | Self | 45 |
| 2020 | Get Organized with The Home EditSeries | — | 45 |
| 2019 | I'm a LA… Get Me Out of Here!Series | Self - Contestant | 44 |
| 2019 | The World's BestSeries | Judge | 44 |
| 2018 | The Joel McHale Show with Joel McHaleSeries | Self - Special Guest | 43 |
| 2018 | The ShopSeries | Self | 43 |
| 2018 | Norm Macdonald Has a ShowSeries | Self - Guest | 43 |
| 2017 | SpielbergMovie | Self | 42 |
| 2017 | Santa Clarita DietSeries | Sheila Hammond | 42 |
| 2016 | ChelseaSeries | Self | 41 |
| 2015 | The Late Show with Stephen ColbertSeries | Self - Guest | 40 |
| 2015 | The Late Late Show with James CordenSeries | Self - Guest | 40 |
| 2015 | Hot OnesSeries | Self | 40 |
| 2015 | Close Up with The Hollywood ReporterSeries | Self | 40 |
| 2015 | Miss You AlreadyMovie | Jess | 40 |
| 2014 | BlendedMovie | Lauren | 39 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self - Guest | 39 |
| 2014 | Late Night with Seth MeyersSeries | Self - Guest | 39 |
| 2012 | The Eric Andre ShowSeries | Self | 37 |
| 2012 | Big MiracleMovie | Rachel Kramer | 37 |
| 2012 | Triple Fisher: The Lethal Lolitas of Long IslandMovie | Amy Fisher (archive footage from "The Amy Fisher Story") | 37 |
| 2012 | The 'E.T.' JournalsMovie | Self | 37 |
| 2011 | Bert Stern - Original MadmanMovie | — | 36 |
| 2010 | Going the DistanceMovie | Erin Rankin Langford | 35 |
| 2009 | Whip ItMovie | Smashley Simpson | 34 |
| 2009 | He's Just Not That Into YouMovie | Mary Harris | 34 |
| 2009 | Watch What Happens Live with Andy CohenSeries | Self - Guest | 34 |
| 2009 | Everybody's FineMovie | Rosie | 34 |
| 2009 | Late Night with Jimmy FallonSeries | Self - Guest | 34 |
| 2009 | The Jay Leno ShowSeries | Self | 34 |
| 2009 | Live from Studio FiveSeries | Self | 34 |
| 2009 | The Tonight Show with Conan O'BrienSeries | Self - Guest | 34 |
| 2009 | Grey GardensMovie | Little Edie | 34 |
| 2009 | Saturday Night Live: The Best of Amy PoehlerMovie | Various (archive footage) | 34 |
| 2008 | Beverly Hills ChihuahuaMovie | Chloe (voice) | 33 |
| 2007 | Lucky YouMovie | Billie Offer | 32 |
| 2007 | Music and LyricsMovie | Sophie Fisher | 32 |
| 2007 | Most Shocking Celebrity Moments of the 80sMovie | Self (archive footage) | 32 |
| 2006 | Curious GeorgeMovie | Maggie (voice) | 31 |
| 2006 | Rachael RaySeries | — | 31 |
| 2006 | Playboy: Celebrity CenterfoldsMovie | Self | 31 |
| 2005 | The Colbert ReportSeries | Self - Guest | 30 |
| 2005 | So You Think You Can DanceSeries | (archive footage) | 30 |
| 2005 | Stewie Griffin: The Untold StoryMovie | Drew Barrymore (voice) | 30 |
| 2005 | My Date with DrewMovie | Self | 30 |
| 2004 | 50 First DatesMovie | Lucy Whitmore | 29 |
| 2004 | Ramones: RawMovie | Self | 29 |
| 2003 | Charlie's Angels: Full ThrottleMovie | Dylan Sanders | 28 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 28 |
| 2003 | Jimmy Kimmel Live!Series | Self - Guest | 28 |
| 2003 | DuplexMovie | Nancy Kendricks | 28 |
| 2003 | Celebrities UncensoredSeries | Self | 28 |
| 2002 | Confessions of a Dangerous MindMovie | Penny | 27 |
| 2002 | Live from E!Series | Self | 27 |
| 2002 | Bo' Selecta!Series | Self | 27 |
| 2002 | The Ultimate Collection starring Johnny Carson - The Best of the 70s and 80sMovie | Self (archive footage) | 27 |
| 2002 | Saturday Night Live: The Best of Will FerrellMovie | Barbara Hernandez (archive footage) | 27 |
| 2002 | PlayersSeries | — | 27 |
| 2002 | E.T. the Extra-Terrestrial 20th Anniversary SpecialMovie | Self | 27 |
| 2001 | Donnie DarkoMovie | Karen Pomeroy | 26 |
| 2001 | Riding in Cars with BoysMovie | Beverly Donofrio | 26 |
| 2001 | Freddy Got FingeredMovie | Davidson's Receptionist | 26 |
| 2001 | Charlie’s Angels: Getting G’d UpMovie | Self | 26 |
| 2001 | Angelic Attire: Dressing Cameron, Drew & LucyMovie | Self | 26 |
| 2001 | Charlie’s Angels: The Master and the AngelsMovie | Self | 26 |
| 2000 | Charlie's AngelsMovie | Dylan Sanders | 25 |
| 2000 | Skipped PartsMovie | Fantasy Girl | 25 |
| 2000 | The Making of Olive, The Other ReindeerMovie | Self | 25 |
| 2000 | Behind the ScreamMovie | Self | 25 |
| 1999 | Family GuySeries | Jillian Russell (voice) | 24 |
| 1999 | Teen Choice AwardsSeries | Self | 24 |
| 1999 | Saturday Night Live: 25th Anniversary SpecialMovie | Self (uncredited) | 24 |
| 1999 | The Early ShowSeries | Self | 24 |
| 1999 | Never Been KissedMovie | Josie Geller | 24 |
| 1999 | Olive, the Other ReindeerMovie | Olive (voice) | 24 |
| 1999 | Wishful ThinkingMovie | Lena | 24 |
| 1998 | The Wedding SingerMovie | Julia Sullivan | 23 |
| 1998 | Home FriesMovie | Sally Jackson | 23 |
| 1998 | EverAfterMovie | Danielle de Barbarac | 23 |
| 1997 | The ViewSeries | Self - Guest | 22 |
| 1997 | Happy Birthday Elizabeth: A Celebration of LifeMovie | Self | 22 |
| 1996 | Everyone Says I Love YouMovie | Skylar Dandridge | 21 |
| 1996 | ScreamMovie | Casey Becker | 21 |
| 1996 | The Daily ShowSeries | Self - Guest | 21 |
| 1996 | E! True Hollywood StorySeries | — | 21 |
| 1996 | The Making of 'E.T. the Extra-Terrestrial'Movie | Self | 21 |
| 1996 | Ruby Wax MeetsSeries | — | 21 |
| 1995 | Batman ForeverMovie | Sugar | 20 |
| 1995 | Saturday Morning: Cartoons' Greatest HitsMovie | Self | 20 |
| 1994 | Inside the Actors StudioSeries | Self | 19 |
| 1994 | Inside the GoldmineMovie | Daisy | 19 |
| 1993 | Wayne's World 2Movie | Bjergen Kjergen | 18 |
| 1993 | Late Show with David LettermanSeries | Self - Guest | 18 |
| 1993 | DoppelgangerMovie | Holly Gooding | 18 |
| 1993 | Bill Nye the Science GuySeries | Herself | 18 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 17 |
| 1992 | The Larry Sanders ShowSeries | Drew Barrymore | 17 |
| 1992 | Sketch ArtistMovie | Daisy Drew | 17 |
| 1992 | Waxwork II: Lost in TimeMovie | Vampire Victim #1 | 17 |
| 1992 | 2000 Malibu RoadSeries | Lindsay Rule | 17 |
| 1992 | Poison IvyMovie | Ivy | 17 |
| 1991 | MotoramaMovie | Fantasy Girl | 16 |
| 1989 | The SimpsonsSeries | Sophie (voice) | 14 |
| 1989 | See You in the MorningMovie | Cathy Goodwin | 14 |
| 1988 | LIVE with Kelly and MarkSeries | — | 13 |
| 1987 | Happy 100th Birthday, HollywoodMovie | Self | 12 |
| 1987 | Citizen SteveMovie | Self - Actress | 12 |
| 1986 | Babes in ToylandMovie | Lisa Piper | 11 |
| 1985 | The Ray Bradbury TheaterSeries | Heather Leary | 10 |
| 1985 | Amazing StoriesSeries | girl on train (cameo) | 10 |
| 1985 | Disneyland's 30th Anniversary CelebrationMovie | Self | 10 |
| 1985 | Cat's EyeMovie | Our Girl | 10 |
| 1985 | The Adventures of Con Sawyer and Hucklemary FinnMovie | Con Sawyer | 10 |
| 1984 | FirestarterMovie | Charlie McGee | 9 |
| 1983 | The Fairest of Them AllMovie | Self | 8 |
| 1982 | E.T. the Extra-TerrestrialMovie | Gertie | 7 |
| 1981 | Entertainment TonightSeries | Self | 6 |
| 1980 | Altered StatesMovie | Margaret Jessup | 5 |
| 1980 | BogieMovie | Leslie Bogart | 5 |
| 1978 | Suddenly, LoveMovie | Bobbi Graham | 3 |
| 1975 | Saturday Night LiveSeries | Self - Host | — |
| 1975 | People's Choice AwardsSeries | Self - Presenter | — |
| 1953 | The OscarsSeries | Self | — |
| 0 | Wake Up America!Series | — | — |
| 0 | Grown Ups 3Movie | — | — |
