Filmography34 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2024 | ReEntryMovie | Elenore | 48 |
| 2019 | The Kelly Clarkson ShowSeries | Self | 43 |
| 2018 | The RookieSeries | Sarah Nolan | 42 |
| 2017 | Carpool Karaoke: The SeriesSeries | Self | 41 |
| 2016 | Animal KingdomSeries | Angela | 40 |
| 2015 | The Late Late Show with James CordenSeries | Self - Guest | 39 |
| 2015 | UnityMovie | Narrator (voice) | 39 |
| 2014 | BoJack HorsemanSeries | Bones (voice) | 38 |
| 2013 | Drunk HistorySeries | Marina Raskova | 37 |
| 2013 | Sleepy HollowSeries | Dr. Temperance Brennan | 37 |
| 2009 | My Sister's KeeperMovie | Dr. Farquad | 33 |
| 2009 | The Cleveland ShowSeries | Emily Deschanel (Voice) | 33 |
| 2009 | Late Night with Jimmy FallonSeries | Self | 33 |
| 2008 | Free RadioSeries | Emily Deschanel | 32 |
| 2006 | Glory RoadMovie | Mary Haskins | 30 |
| 2005 | BonesSeries | Temperance 'Bones' Brennan | 29 |
| 2005 | American Dad!Series | Emily Deschanel (voice) | 29 |
| 2005 | The Late Late Show with Craig FergusonSeries | — | 29 |
| 2005 | The Reichen ShowSeries | Self | 29 |
| 2004 | Spider-Man 2Movie | Receptionist | 28 |
| 2004 | The AlamoMovie | Rosanna Travis | 28 |
| 2003 | Jimmy Kimmel Live!Series | Self | 27 |
| 2003 | Cold MountainMovie | Mrs. Morgan | 27 |
| 2002 | Rose RedSeries | Pam Asbury | 26 |
| 2001 | Crossing JordanSeries | Michelle | 25 |
| 1999 | Law & Order: Special Victims UnitSeries | Cassie Germaine | 23 |
| 1999 | ProvidenceSeries | Annie Frank | 23 |
| 1997 | The ViewSeries | Self | 21 |
| 1994 | It Could Happen to YouMovie | Paint-Throwing Fur Activist | 18 |
| 1993 | Late Night with Conan O'BrienSeries | Self - Guest | 17 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 16 |
| 1989 | The SimpsonsSeries | Emily Deschanel (voice) | 13 |
| 1975 | People's Choice AwardsSeries | Self - Presenter | — |
| 0 | Friend ThingMovie | Anne Madsen | — |