Filmography46 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2022 | Women TalkingMovie | Scarface Janz | 65 |
| 2021 | The French Dispatch of the Liberty, Kansas Evening SunMovie | Lucinda Krementz | 64 |
| 2021 | NomadlandMovie | Fern | 64 |
| 2019 | Good OmensSeries | God (voice) | 62 |
| 2018 | Isle of DogsMovie | Interpreter Nelson (voice) | 61 |
| 2017 | Three Billboards Outside Ebbing, MissouriMovie | Mildred | 60 |
| 2017 | The Untold Tales of Armistead MaupinMovie | Self (voice) | 60 |
| 2016 | Hail, Caesar!Movie | C. C. Calhoun | 59 |
| 2015 | The Good DinosaurMovie | Momma (voice) | 58 |
| 2014 | Olive KitteridgeSeries | Olive Kitteridge | 57 |
| 2012 | Madagascar 3: Europe's Most WantedMovie | Captain Chantel DuBois (voice) | 55 |
| 2012 | Moonrise KingdomMovie | Mrs. Bishop | 55 |
| 2011 | Transformers: Dark of the MoonMovie | Mearing | 54 |
| 2011 | This Must Be the PlaceMovie | Jane | 54 |
| 2008 | Miss Pettigrew Lives for a DayMovie | Guinevere Pettigrew | 51 |
| 2005 | Æon FluxMovie | Handler | 48 |
| 2003 | Something's Gotta GiveMovie | Zoe | 46 |
| 2003 | Laurel CanyonMovie | Jane | 46 |
| 2002 | Searching for Debra WingerMovie | Self | 45 |
| 2002 | City by the SeaMovie | Michelle | 45 |
| 2001 | The Man Who Wasn't ThereMovie | Doris Crane | 44 |
| 2001 | State of GraceSeries | Adult Hannah (voice) | 44 |
| 2000 | Wonder BoysMovie | Sara Gaskell | 43 |
| 2000 | Almost FamousMovie | Elaine Miller | 43 |
| 1998 | Johnny SkidmarksMovie | Alice | 41 |
| 1997 | Paradise RoadMovie | Dr. Verstak | 40 |
| 1996 | Primal FearMovie | Molly | 39 |
| 1996 | FargoMovie | Marge Gunderson | 39 |
| 1993 | Short CutsMovie | Betty Weathers | 36 |
| 1992 | Passed AwayMovie | Nora Scanlan | 35 |
| 1991 | The Butcher's WifeMovie | Grace | 34 |
| 1991 | Barton FinkMovie | Stage Actress (voice) (uncredited) | 34 |
| 1990 | DarkmanMovie | Julie Hastings | 33 |
| 1990 | Miller's CrossingMovie | Mayor's Secretary (uncredited) | 33 |
| 1990 | Hidden AgendaMovie | Ingrid Jessner | 33 |
| 1989 | The SimpsonsSeries | Melanie Upfoot (voice) | 32 |
| 1988 | Mississippi BurningMovie | Mrs. Pell | 31 |
| 1987 | Leg WorkSeries | Willie Pipal | 30 |
| 1987 | Raising ArizonaMovie | Dot | 30 |
| 1986 | Vengeance: The Story of Tony CimoMovie | Brigette | 29 |
| 1985 | The Twilight ZoneSeries | (segment "Need to Know") | 28 |
| 1985 | CrimewaveMovie | Nun | 28 |
| 1985 | Blood SimpleMovie | Abby | 28 |
| 1985 | Scandal SheetMovie | — | 28 |
| 1984 | HunterSeries | Nina Sloan | 27 |
| 1953 | The OscarsSeries | Self | — |