Filmography40 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | The Sixty Year Mission: How Star Trek Changed Television and the WorldMovie | Self | 77 |
| 2026 | The Center Seat II: 60 Years of Star TrekSeries | Narrator | 77 |
| 2024 | X-Men '97Series | Mother Askani (voice) | 75 |
| 2023 | Star Trek: very Short TreksSeries | Dr. Crusher (voice) | 74 |
| 2022 | The Shuttlepod ShowSeries | Self | 73 |
| 2021 | Star Trek: ProdigySeries | Beverly Crusher (voice) | 72 |
| 2020 | Star Trek: PicardSeries | Dr. Beverly Crusher | 71 |
| 2020 | Hexengeddon: Witches vs. the WorldMovie | Madame Hexxina | 71 |
| 2019 | That Guy... Who Was In That Thing 3: Trek StarsMovie | Self & Narrator | 70 |
| 2019 | The Ready RoomSeries | Self | 70 |
| 2016 | 50 Years of Star TrekMovie | Self | 67 |
| 2014 | Star Trek: The Next Generation - Chain of CommandMovie | Dr. Beverly Crusher | 65 |
| 2014 | Star Trek: The Next Generation - All Good Things...Movie | Dr. Beverly Crusher | 65 |
| 2013 | Star Trek: The Next Generation - RedemptionMovie | Dr. Beverly Crusher | 64 |
| 2013 | The Captains Close UpSeries | Self | 64 |
| 2011 | Franklin & BashSeries | Judge Mallory Jacobs | 62 |
| 2009 | Make the Yuletide GayMovie | Martha Stanford | 60 |
| 2005 | DirtyMovie | Wife | 56 |
| 2003 | NCISSeries | Mrs. Belmont | 54 |
| 2001 | The DivisionSeries | Mrs. Petersen | 52 |
| 1999 | Family GuySeries | Gates McFadden (voice) | 50 |
| 1998 | Star Trek: InsurrectionMovie | Doctor Beverly Crusher | 49 |
| 1997 | The PracticeSeries | Judge Emily Harrison | 48 |
| 1997 | Crowned and DangerousMovie | Patrice Baxter | 48 |
| 1996 | Star Trek: First ContactMovie | Commander Beverly Crusher | 47 |
| 1996 | Star Trek: 30 Years and BeyondMovie | Self | 47 |
| 1995 | MarkerSeries | Kimba | 46 |
| 1994 | Party of FiveSeries | Greer Erikson | 45 |
| 1994 | Star Trek: GenerationsMovie | Dr. Beverly Crusher | 45 |
| 1992 | Mad About YouSeries | Allison Rourke | 43 |
| 1990 | Dream OnSeries | Ina Dreikoff | 41 |
| 1990 | The Hunt for Red OctoberMovie | Caroline Ryan | 41 |
| 1990 | Taking Care of BusinessMovie | Diane Connors | 41 |
| 1987 | Star Trek: The Next GenerationSeries | Beverly Crusher | 38 |
| 1986 | The WizardSeries | — | 37 |
| 1986 | Inside the LabyrinthMovie | Self | 37 |
| 1984 | The Cosby ShowSeries | — | 35 |
| 1984 | The Muppets Take ManhattanMovie | Mr. Price's Secretary | 35 |
| 1975 | Saturday Night LiveSeries | Woman in audience kissed by Bill Murray (uncredited) | 26 |
| 0 | Make-Up Man: The Michael Westmore DocumentaryMovie | Self | — |