Filmography89 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | Teenage Sex and Death at Camp MiasmaMovie | Billie | 58 |
| 2025 | TRON: AresMovie | Elisabeth Dillinger | 57 |
| 2025 | The AbandonsSeries | Constance Van Ness | 57 |
| 2025 | The Salt PathMovie | Raynor Winn | 57 |
| 2025 | TrespassesSeries | Gina | 57 |
| 2024 | ScoopMovie | Emily Maitlis | 56 |
| 2023 | White BirdMovie | Vivienne Beaumier | 55 |
| 2022 | The First LadySeries | Eleanor Roosevelt | 54 |
| 2022 | The Pale Blue EyeMovie | Julia Marquis | 54 |
| 2021 | Robin RobinMovie | Cat (voice) | 53 |
| 2020 | The SavoySeries | Self | 52 |
| 2019 | Sex EducationSeries | Jean Milburn | 51 |
| 2019 | This Changes EverythingMovie | Self | 51 |
| 2019 | National Theatre Live: All About EveMovie | Margo Channing | 51 |
| 2018 | The Spy Who Dumped MeMovie | Wendy | 50 |
| 2018 | UFOMovie | Dr. Hendricks | 50 |
| 2017 | American GodsSeries | Media | 49 |
| 2017 | Heroes ManufacturedMovie | Self (archive footage) | 49 |
| 2017 | Viceroy's HouseMovie | Edwina Mountbatten | 49 |
| 2017 | Crooked HouseMovie | Magda Leonides | 49 |
| 2017 | Woolf WorksMovie | Voiceover from a letter by Virginia Woolf (voice) | 49 |
| 2016 | The CrownSeries | Margaret Thatcher | 48 |
| 2016 | War and PeaceSeries | Anna Pavlovna Scherer | 48 |
| 2016 | WIRED's Autocomplete InterviewsSeries | Self - Guide | 48 |
| 2016 | SoldMovie | Sophia | 48 |
| 2015 | The Late Show with Stephen ColbertSeries | Self - Guest | 47 |
| 2015 | The Late Late Show with James CordenSeries | Self - Guest | 47 |
| 2015 | Getting the Old Scent Again: Reimagining Red DragonMovie | Self | 47 |
| 2015 | Robot OverlordsMovie | Kate | 47 |
| 2015 | The WidowmakerMovie | Narrator | 47 |
| 2014 | Ronja, the Robber's DaughterSeries | Narrator | 46 |
| 2014 | CrisisSeries | Meg Fitch | 46 |
| 2014 | Variety Studio: Actors on ActorsSeries | Self | 46 |
| 2014 | Late Night with Seth MeyersSeries | Self - Guest | 46 |
| 2014 | National Theatre Live: A Streetcar Named DesireMovie | Blanche DuBois | 46 |
| 2013 | HannibalSeries | Dr. Bedelia Du Maurier | 45 |
| 2013 | The FallSeries | Stella Gibson | 45 |
| 2013 | Mr. Morgan's Last LoveMovie | Karen Morgan | 45 |
| 2013 | I'll Follow You DownMovie | Marika Whyte | 45 |
| 2012 | FOX 25th Anniversary SpecialMovie | Self | 44 |
| 2012 | Shadow DancerMovie | Kate Fletcher | 44 |
| 2012 | SisterMovie | Kristin Jansen | 44 |
| 2012 | Room on the BroomMovie | Witch (voice) | 44 |
| 2011 | Great ExpectationsSeries | Miss Havisham | 43 |
| 2011 | Johnny English RebornMovie | Pamela | 43 |
| 2011 | The Crimson Petal and the WhiteSeries | Mrs. Castaway | 43 |
| 2011 | Moby DickSeries | Elizabeth | 43 |
| 2010 | Boogie WoogieMovie | Jean Maclestone | 42 |
| 2010 | Any Human HeartSeries | Duchess Of Windsor | 42 |
| 2010 | No PressureMovie | Self | 42 |
| 2009 | Watch What Happens Live with Andy CohenSeries | Self - Guest | 41 |
| 2008 | How to Lose Friends & Alienate PeopleMovie | Eleanor Johnson | 40 |
| 2008 | The X-Files: I Want to BelieveMovie | Dana Scully | 40 |
| 2007 | The Graham Norton ShowSeries | Self | 39 |
| 2007 | Robbie the Reindeer in Close Encounters of the Herd KindMovie | Queen Vorkana (voice) | 39 |
| 2007 | StraightheadsMovie | Alice | 39 |
| 2006 | The Last King of ScotlandMovie | Sarah Merrit | 38 |
| 2005 | Bleak HouseSeries | Lady Dedlock | 37 |
| 2005 | A Cock and Bull StoryMovie | Widow Wadman / Gillian Anderson | 37 |
| 2004 | ParkinsonSeries | Self - Guest | 36 |
| 2003 | Jimmy Kimmel Live!Series | Self - Guest | 35 |
| 2003 | Celebrities UncensoredSeries | Self | 35 |
| 2002 | American IdolSeries | Self | 34 |
| 2002 | V Graham NortonSeries | Self | 34 |
| 2002 | Top GearSeries | Self | 34 |
| 2001 | Richard & JudySeries | Self | 33 |
| 2000 | The House of MirthMovie | Lily Bart | 32 |
| 1999 | Harsh RealmSeries | Video Narrator (uncredited) | 31 |
| 1998 | The X-FilesMovie | Agent Dana Scully | 30 |
| 1998 | Playing by HeartMovie | Meredith | 30 |
| 1998 | The MightyMovie | Loretta Lee | 30 |
| 1998 | ParkinsonSeries | Self | 30 |
| 1998 | Chicago CabMovie | Southside Girl | 30 |
| 1998 | Inside The X-FilesMovie | Self | 30 |
| 1998 | The Making of 'The X Files: Fight the Future'Movie | Self | 30 |
| 1998 | The Magic HourSeries | Self | 30 |
| 1996 | More Secrets of the X-FilesMovie | Self | 28 |
| 1996 | The Rosie O'Donnell ShowSeries | Self - Guest | 28 |
| 1996 | Future FantasticSeries | Self - Host | 28 |
| 1994 | ReBootSeries | Data Nully (voice) | 26 |
| 1993 | FrasierSeries | Jenny (voice) | 25 |
| 1993 | The X-FilesSeries | Dana Scully | 25 |
| 1993 | Class of '96Series | Rachel | 25 |
| 1992 | Eek! The CatSeries | Dana Scully (voice) | 24 |
| 1992 | The Tonight Show with Jay LenoSeries | Self - Guest | 24 |
| 1992 | The TurningMovie | April Cavanaugh | 24 |
| 1989 | The SimpsonsSeries | Dana Scully (voice) | 21 |
| 1988 | This MorningSeries | Self - Guest | 20 |
| 1944 | Golden Globe AwardsSeries | Self - Presenter | — |