Filmography107 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | The Dog StarsMovie | Bangley | 58 |
| 2026 | Dune: Part ThreeMovie | Gurney Halleck | 58 |
| 2026 | WhalefallMovie | Mitt Gardiner | 58 |
| 2025 | Wake Up Dead Man: A Knives Out MysteryMovie | Mons. Jefferson Wicks | 57 |
| 2025 | Ladies & Gentlemen... 50 Years of SNL MusicMovie | Self (archive footage) | 57 |
| 2025 | Breakdown: 1975Movie | Self | 57 |
| 2025 | The American RevolutionSeries | George Washington (voice) | 57 |
| 2025 | WeaponsMovie | Archer | 57 |
| 2025 | Kerouac's Road: The Beat of a NationMovie | Self | 57 |
| 2024 | Dune: Part TwoMovie | Gurney Halleck | 56 |
| 2024 | BrothersMovie | Moke Munger | 56 |
| 2023 | N-Men: The Untold StoryMovie | John O’Shei | 55 |
| 2022 | Outer RangeSeries | Royal Abbott | 54 |
| 2021 | Marvel Studios LegendsSeries | Thanos (archive footage) (uncredited) | 53 |
| 2021 | What If...?Series | Thanos (voice) | 53 |
| 2021 | DuneMovie | Gurney Halleck | 53 |
| 2021 | Flag DayMovie | Uncle Beck | 53 |
| 2020 | Chadwick Boseman: A Tribute for a KingMovie | Self | 52 |
| 2020 | Reunited ApartSeries | Self | 52 |
| 2020 | Russo Bros. Pizza Film SchoolSeries | — | 52 |
| 2019 | Avengers: EndgameMovie | Thanos | 51 |
| 2019 | The Kelly Clarkson ShowSeries | Self | 51 |
| 2018 | Avengers: Infinity WarMovie | Thanos | 50 |
| 2018 | Deadpool 2Movie | Cable | 50 |
| 2018 | Once Upon a DeadpoolMovie | Cable | 50 |
| 2018 | Sicario: Day of the SoldadoMovie | Matt Graver | 50 |
| 2018 | The Legacy of a Whitetail Deer HunterMovie | Buck Ferguson | 50 |
| 2017 | Only the BraveMovie | Eric Marsh | 49 |
| 2016 | Hail, Caesar!Movie | Eddie Mannix | 48 |
| 2016 | WIRED's Autocomplete InterviewsSeries | Self - Guest | 48 |
| 2016 | Unchained: The Untold Story of Freestyle MotocrossMovie | Narrator (voice) | 48 |
| 2015 | Avengers: Age of UltronMovie | Thanos (uncredited) | 47 |
| 2015 | The Late Show with Stephen ColbertSeries | Self - Guest | 47 |
| 2015 | SicarioMovie | Matt Graver | 47 |
| 2015 | EverestMovie | Beck Weathers | 47 |
| 2015 | Hot OnesSeries | Self | 47 |
| 2015 | Chryskylodon BluesMovie | Self | 47 |
| 2014 | Guardians of the GalaxyMovie | Thanos (uncredited) | 46 |
| 2014 | Sin City: A Dame to Kill ForMovie | Dwight | 46 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self | 46 |
| 2014 | Variety Studio: Actors on ActorsSeries | Self | 46 |
| 2014 | Late Night with Seth MeyersSeries | Self - Guest | 46 |
| 2014 | Inherent ViceMovie | Lt. Det. Christian F. "Bigfoot" Bjornsen | 46 |
| 2013 | Gangster SquadMovie | John O'Mara | 45 |
| 2012 | RadiomanMovie | Self | 44 |
| 2012 | Men in Black 3Movie | Young Agent K | 44 |
| 2011 | Woody Allen: A DocumentaryMovie | Self | 43 |
| 2010 | You Will Meet a Tall Dark StrangerMovie | Roy | 42 |
| 2010 | The Women of SNLMovie | Various (archive footage) | 42 |
| 2010 | True GritMovie | Tom Chaney | 42 |
| 2010 | Wall Street: Money Never SleepsMovie | Bretton James | 42 |
| 2010 | Jonah HexMovie | Jonah Hex | 42 |
| 2010 | The Tillman StoryMovie | Narrator (voice) | 42 |
| 2009 | The Tonight Show with Conan O'BrienSeries | Self - Guest | 41 |
| 2009 | Women in TroubleMovie | Nick Chapel | 41 |
| 2009 | Saturday Night Live: The Best of Amy PoehlerMovie | Bar Guy (archive footage) | 41 |
| 2008 | W.Movie | George W. Bush | 40 |
| 2008 | Fantastic Flesh: The Art of Make-Up EFXMovie | Self | 40 |
| 2008 | MilkMovie | Dan White | 40 |
| 2008 | Behind the Scenes of 'No Country for Old Men': An Incredibly Unauthorized DocumentaryMovie | Self | 40 |
| 2008 | Stand Up to CancerSeries | Self | 40 |
| 2008 | The Making of 'No Country for Old Men'Movie | Self - Llewelyn Moss | 40 |
| 2007 | No Country for Old MenMovie | Llewelyn Moss | 39 |
| 2007 | Planet TerrorMovie | Dr. William Block | 39 |
| 2007 | GrindhouseMovie | Block (segment "Planet Terror") | 39 |
| 2007 | The Graham Norton ShowSeries | Self - Guest | 39 |
| 2007 | To Each His Own CinemaMovie | (segment "World cinema") | 39 |
| 2007 | In the Valley of ElahMovie | Chief Buchwald | 39 |
| 2007 | American GangsterMovie | Detective Trupo | 39 |
| 2006 | The Dead GirlMovie | Tarlow | 38 |
| 2005 | Into the WestSeries | Jedediah Smith | 37 |
| 2005 | Into the BlueMovie | Bates | 37 |
| 2003 | Jimmy Kimmel Live!Series | Self - Guest | 35 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 35 |
| 2003 | Mister SterlingSeries | Bill Sterling | 35 |
| 2003 | Milwaukee, MinnesotaMovie | Gary | 35 |
| 2002 | CoastlinesMovie | Dave Lockhart | 34 |
| 2001 | LorraineSeries | Self | 33 |
| 2000 | Hollow ManMovie | Matthew Kensington | 32 |
| 2000 | Slow BurnMovie | Duster | 32 |
| 2000 | PicnicMovie | Hal Carter | 32 |
| 1999 | The Mod SquadMovie | Billy Waites | 31 |
| 1999 | All the RageMovie | Tennel | 31 |
| 1997 | The ViewSeries | Self | 29 |
| 1997 | My Brother's WarMovie | Pete | 29 |
| 1997 | MimicMovie | Josh | 29 |
| 1996 | The Daily ShowSeries | Self - Guest | 28 |
| 1996 | Flirting with DisasterMovie | Tony Kent | 28 |
| 1996 | Bed of RosesMovie | Danny | 28 |
| 1995 | The Outer LimitsSeries | Jack Pierce | 27 |
| 1994 | The Road KillersMovie | Tom | 26 |
| 1993 | Late Show with David LettermanSeries | Self - Guest | 25 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 24 |
| 1989 | The Young RidersSeries | Wild Bill Hickok | 21 |
| 1989 | Finish LineMovie | Glenn Shrevelow | 21 |
| 1988 | LIVE with Kelly and MarkSeries | Self - Guest | 20 |
| 1987 | 21 Jump StreetSeries | Taylor Rolator | 19 |
| 1987 | Prison for ChildrenMovie | Boise | 19 |
| 1987 | Private EyeSeries | Johnny Betts | 19 |
| 1986 | Thrashin'Movie | Corey Webster | 18 |
| 1985 | The GooniesMovie | Brand | 17 |
| 1985 | The Making Of The GooniesMovie | Self | 17 |
| 1984 | Highway to HeavenSeries | — | 16 |
| 1981 | Entertainment TonightSeries | Self | 13 |
| 1975 | Saturday Night LiveSeries | Self - Host | 7 |
| 1953 | The OscarsSeries | Self | — |
| 0 | Fleshing Out the Hollow ManMovie | Self | — |