Filmography108 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2025 | After the HuntMovie | Alma Imhoff | 58 |
| 2025 | Matthew Perry: A Hollywood TragedyMovie | Self (archive footage) | 58 |
| 2025 | Variety & CNN Actors on ActorsSeries | Self | 58 |
| 2024 | 2024 Rock & Roll Hall of Fame Induction CeremonyMovie | Self | 57 |
| 2023 | Leave the World BehindMovie | Amanda Sandford | 56 |
| 2023 | Tom Hanks: The NomadMovie | Self (archive footage) | 56 |
| 2022 | GaslitSeries | Martha Mitchell | 55 |
| 2022 | Ticket to ParadiseMovie | Georgia Cotton | 55 |
| 2020 | The Happy Days of Garry MarshallMovie | Self | 53 |
| 2019 | The Kelly Clarkson ShowSeries | Self | 52 |
| 2018 | Ben Is BackMovie | Holly Burns | 51 |
| 2018 | HomecomingSeries | Heidi Bergman | 51 |
| 2018 | Busy TonightSeries | Self - Guest | 51 |
| 2017 | WonderMovie | Isabel | 50 |
| 2017 | Smurfs: The Lost VillageMovie | Smurfwillow (voice) | 50 |
| 2017 | Bright Lights: Starring Carrie Fisher and Debbie ReynoldsMovie | Self (archive footage, uncredited) | 50 |
| 2016 | Mother's DayMovie | Miranda Collins | 49 |
| 2016 | Money MonsterMovie | Patty Fenn | 49 |
| 2016 | WIRED's Autocomplete InterviewsSeries | Self - Guest | 49 |
| 2015 | The Late Show with Stephen ColbertSeries | Self - Guest | 48 |
| 2015 | Nature Is SpeakingSeries | Mother Nature | 48 |
| 2015 | Secret in Their EyesMovie | Jess | 48 |
| 2015 | Schitt's CreekSeries | Erin Brockovich (voice) | 48 |
| 2015 | Taylor Swift: The 1989 World Tour - LiveMovie | Self - Special Guest | 48 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self - Guest | 47 |
| 2014 | Variety Studio: Actors on ActorsSeries | Self | 47 |
| 2014 | The Normal HeartMovie | Dr. Emma Brookner | 47 |
| 2014 | Running Wild with Bear GryllsSeries | Self | 47 |
| 2014 | Trailblazer HonorsSeries | Self | 47 |
| 2013 | August: Osage CountyMovie | Barbara Weston | 46 |
| 2012 | Mirror MirrorMovie | Evil Queen | 45 |
| 2011 | Larry CrowneMovie | Mercedes Tainot | 44 |
| 2011 | His WayMovie | Self | 44 |
| 2010 | Valentine's DayMovie | Captain Kate Hazeltine | 43 |
| 2010 | Eat Pray LoveMovie | Elizabeth 'Liz' Gilbert | 43 |
| 2009 | Watch What Happens Live with Andy CohenSeries | Self - Guest | 42 |
| 2009 | DuplicityMovie | Claire Stenwick | 42 |
| 2008 | Fireflies in the GardenMovie | Lisa Waechter | 41 |
| 2007 | The Graham Norton ShowSeries | Self | 40 |
| 2007 | Charlie Wilson's WarMovie | Joanne Herring | 40 |
| 2007 | Annie Leibovitz: Life Through a LensMovie | Self | 40 |
| 2007 | AFI: 100 Years... 100 Movies... 10th Anniversary EditionMovie | Self | 40 |
| 2006 | Charlotte's WebMovie | Charlotte the Spider (voice) | 39 |
| 2006 | The Ant BullyMovie | Hova (voice) | 39 |
| 2006 | Who Needs Sleep?Movie | Self | 39 |
| 2005 | The Reichen ShowSeries | Self | 38 |
| 2005 | Shelter from the Storm: A Concert for the Gulf CoastMovie | Self - Presenter | 38 |
| 2004 | CloserMovie | Anna | 37 |
| 2004 | Ocean's TwelveMovie | Tess Ocean | 37 |
| 2004 | Tell Them Who You AreMovie | Self | 37 |
| 2003 | Jimmy Kimmel Live!Series | Self | 36 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 36 |
| 2003 | Mona Lisa SmileMovie | Katherine Ann Watson | 36 |
| 2002 | Confessions of a Dangerous MindMovie | Patricia Watson | 35 |
| 2002 | Full FrontalMovie | Francesca / Catherine | 35 |
| 2002 | 'Ocean's Eleven': The Look of the ConMovie | Self | 35 |
| 2001 | Ocean's ElevenMovie | Tess Ocean | 34 |
| 2001 | America's SweetheartsMovie | Kathleen 'Kiki' Harrison | 34 |
| 2001 | The MexicanMovie | Samantha Barzel | 34 |
| 2001 | America | A Tribute to HeroesMovie | Self | 34 |
| 2000 | Erin BrockovichMovie | Erin Brockovich | 33 |
| 2000 | Light Keeps Me CompanyMovie | Self | 33 |
| 1999 | Notting HillMovie | Anna Scott | 32 |
| 1999 | Runaway BrideMovie | Maggie Carpenter | 32 |
| 1998 | StepmomMovie | Isabel Kelly | 31 |
| 1998 | The Entertainment BizSeries | Self | 31 |
| 1997 | My Best Friend's WeddingMovie | Julianne Potter | 30 |
| 1997 | Conspiracy TheoryMovie | Alice Sutton | 30 |
| 1997 | Sesame Street: Elmo Says BOO!Movie | Self | 30 |
| 1996 | Everyone Says I Love YouMovie | Von Sidell | 29 |
| 1996 | E! True Hollywood StorySeries | — | 29 |
| 1996 | Mary ReillyMovie | Mary Reilly | 29 |
| 1996 | Michael CollinsMovie | Kitty Kiernan | 29 |
| 1996 | Shirley Maclaine: Kicking Up Her HeelsMovie | Self (archive footage) | 29 |
| 1995 | Something to Talk AboutMovie | Grace King Bichon | 28 |
| 1994 | FriendsSeries | Susie | 27 |
| 1994 | Prêt-à-PorterMovie | Anne Eisenhower | 27 |
| 1994 | I Love TroubleMovie | Sabrina Peterson | 27 |
| 1994 | Inside the Actors StudioSeries | Self | 27 |
| 1993 | The Pelican BriefMovie | Darby Shaw | 26 |
| 1993 | Sesame Street's 25th Birthday: A Musical CelebrationMovie | Self (segment "Monster in the Mirror") | 26 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 25 |
| 1992 | The PlayerMovie | Julia Roberts | 25 |
| 1991 | HookMovie | Tinkerbell | 24 |
| 1991 | Dying YoungMovie | Hilary O'Neil | 24 |
| 1991 | Sleeping with the EnemyMovie | Laura Burney / Sara Walters | 24 |
| 1991 | Pebble MillSeries | Self | 24 |
| 1990 | Law & OrderSeries | Katrina Ludlow | 23 |
| 1990 | Pretty WomanMovie | Vivian Ward | 23 |
| 1990 | FlatlinersMovie | Rachel Mannus | 23 |
| 1989 | Steel MagnoliasMovie | Shelby Eatenton Latcherie | 22 |
| 1989 | Blood RedMovie | Maria Collogero | 22 |
| 1988 | Murphy BrownSeries | — | 21 |
| 1988 | Mystic PizzaMovie | Daisy | 21 |
| 1988 | Baja OklahomaMovie | Candy Hutchins | 21 |
| 1987 | FirehouseMovie | Babs (uncredited) | 20 |
| 1986 | Crime StorySeries | Tracy | 19 |
| 1986 | American MastersSeries | Self | 19 |
| 1984 | Miami ViceSeries | Polly Wheeler | 17 |
| 1982 | NatureSeries | Host | 15 |
| 1982 | Late Night with David LettermanSeries | Self | 15 |
| 1981 | Entertainment TonightSeries | Self | 14 |
| 1976 | Cérémonie des CésarSeries | Self - Recipient | 9 |
| 1973 | The American Film Institute Salute to ...Series | Self | 6 |
| 1969 | Sesame StreetSeries | Self | 2 |
| 1953 | The OscarsSeries | Self | — |
| 1952 | TodaySeries | Self | — |
| 1944 | Golden Globe AwardsSeries | Self - Nominee / Presenter | — |