Filmography44 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | Yellow MirrorMovie | Marge Simpson / Jacqueline Bouvier (voice) | 76 |
| 2026 | Extreme Makeover: Homer EditionMovie | Marge Simpson (voice) | 76 |
| 2026 | SimpsleyMovie | Marge Bouvier (voice) | 76 |
| 2025 | Ella McCayMovie | Estelle | 75 |
| 2022 | The Simpsons Meet the Bocellis in "Feliz Navidad"Movie | Marge Simpson (voice) | 72 |
| 2020 | Dear Class of 2020Movie | Marge Simpson | 70 |
| 2012 | FOX 25th Anniversary SpecialMovie | Marge Simpson (voice) (uncredited) | 62 |
| 2011 | Woody Allen: A DocumentaryMovie | Self | 61 |
| 2011 | James L. Brooks: A Singular VoiceMovie | Self | 61 |
| 2010 | The Simpsons 20th Anniversary Special - In 3D! On Ice!Movie | Self | 60 |
| 2007 | The Simpsons MovieMovie | Marge Simpson / Selma Bouvier / Patty Bouvier (voice) | 57 |
| 2006 | ClickMovie | Trudy | 56 |
| 2001 | Story of a Bad BoyMovie | Elaine | 51 |
| 2000 | The Simpsons: America's First FamilyMovie | Self | 50 |
| 2000 | CyberWorldMovie | Marge Simpson / Patty Bouvier / Selma Bouvier (voice) | 50 |
| 1999 | Family GuySeries | Marge Simpson / Patty Bouvier / Selma Bouvier (voice) | 49 |
| 1999 | Judy BerlinMovie | Marie | 49 |
| 1999 | A Walk on the MoonMovie | P.A. Announcer (voice) | 49 |
| 1998 | Doctor DolittleMovie | Female Pigeon (voice) | 48 |
| 1997 | Deconstructing HarryMovie | Grace | 47 |
| 1996 | Tracey Takes On...Series | Jodie Wolf / Midge Dexter | 46 |
| 1995 | Forget ParisMovie | Lucy | 45 |
| 1994 | Don't Drink the WaterMovie | Marion Hollander | 44 |
| 1994 | I'll Do AnythingMovie | Nan Mulhanney | 44 |
| 1993 | Late Show with David LettermanSeries | Marge Simpson (voice) | 43 |
| 1993 | Sesame Street's 25th Birthday: A Musical CelebrationMovie | Marge Simpson (voice) (segment "Monster in the Mirror") (uncredited) | 43 |
| 1992 | This Is My LifeMovie | Dottie Ingels | 42 |
| 1991 | Shadows and FogMovie | Alma | 41 |
| 1990 | AliceMovie | Decorator | 40 |
| 1990 | AwakeningsMovie | Eleanor Costello | 40 |
| 1989 | The SimpsonsSeries | Marge Simpson / Patty Bouvier / Selma Bouvier (voice) | 39 |
| 1989 | New York StoriesMovie | Treva | 39 |
| 1987 | The Tracey Ullman ShowSeries | — | 37 |
| 1987 | Radio DaysMovie | Mother | 37 |
| 1987 | SurrenderMovie | Ronnie | 37 |
| 1986 | Hannah and Her SistersMovie | Gail | 36 |
| 1982 | National Lampoon's Movie MadnessMovie | Mrs. Falcone ("Municipalians") | 32 |
| 1980 | Revenge of the Stepford WivesMovie | Megan Brady | 30 |
| 1979 | No Other LoveMovie | Janet Michaels | 29 |
| 1978 | TaxiSeries | Monica Banta Douglas | 28 |
| 1977 | Lou GrantSeries | Alice Merrin | 27 |
| 1974 | PetrocelliSeries | — | 24 |
| 1974 | RhodaSeries | Brenda Morgenstern | 24 |
| 1973 | The Dean Martin Celebrity RoastsSeries | Self | 23 |