Filmography106 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | Masters of the UniverseMovie | Roboto (voice) | 53 |
| 2026 | LorneMovie | Self | 53 |
| 2026 | Sia: Nostalgic for the PresentMovie | — | 53 |
| 2025 | SNL50: The Homecoming ConcertMovie | Self | 52 |
| 2025 | Ladies & Gentlemen... 50 Years of SNL MusicMovie | Self | 52 |
| 2025 | Gabby's Dollhouse: The MovieMovie | Vera | 52 |
| 2025 | Good Hang with Amy PoehlerSeries | Self - Guest | 52 |
| 2024 | Despicable Me 4Movie | Lucy (voice) | 51 |
| 2024 | Will & HarperMovie | Self | 51 |
| 2024 | Sausage Party: FoodtopiaSeries | Brenda (voice) | 51 |
| 2024 | Palm RoyaleSeries | Maxine Dellacorte | 51 |
| 2023 | Off Script with The Hollywood ReporterSeries | Self | 50 |
| 2023 | Carol Burnett: 90 Years of Laughter + LoveMovie | Self - Guest | 50 |
| 2021 | A Boy Called ChristmasMovie | Aunt Carlotta | 48 |
| 2021 | Barb & Star Go to Vista Del MarMovie | Star / Sharon Gordon Fisherman | 48 |
| 2021 | MacGruberSeries | Vicki St. Elmo | 48 |
| 2020 | The Drew Barrymore ShowSeries | Self | 47 |
| 2020 | Wonder Woman 1984Movie | Barbara Minerva | 47 |
| 2019 | The Kelly Clarkson ShowSeries | Self | 46 |
| 2019 | How to Train Your Dragon: The Hidden WorldMovie | Ruffnut (voice) | 46 |
| 2019 | Bless the HartsSeries | Jenny Hart (voice) | 46 |
| 2019 | Where'd You Go, BernadetteMovie | Audrey | 46 |
| 2017 | mother!Movie | Herald | 44 |
| 2017 | Big MouthSeries | Jessi's Vagina (voice) | 44 |
| 2017 | Despicable Me 3Movie | Lucy Wilde (voice) | 44 |
| 2017 | Wet Hot American Summer: Ten Years LaterSeries | Courtney | 44 |
| 2017 | DownsizingMovie | Audrey Safranek | 44 |
| 2016 | GhostbustersMovie | Erin Gilbert | 43 |
| 2016 | Sausage PartyMovie | Brenda (voice) | 43 |
| 2016 | Zoolander 2Movie | Alexanya Atoz | 43 |
| 2016 | WIRED's Autocomplete InterviewsSeries | Self - Guest | 43 |
| 2016 | MastermindsMovie | Kelly Campbell | 43 |
| 2016 | The 4%: Film's Gender ProblemMovie | Self | 43 |
| 2015 | The MartianMovie | Annie Montrose | 42 |
| 2015 | The Late Show with Stephen ColbertSeries | Self | 42 |
| 2015 | ARES: liveSeries | Annie Montrose | 42 |
| 2015 | UnityMovie | Narrator (voice) | 42 |
| 2015 | The Spoils Before DyingSeries | Delores O'Dell | 42 |
| 2015 | The Diary of a Teenage GirlMovie | Charlotte Worthington | 42 |
| 2015 | Welcome to MeMovie | Alice Klieg | 42 |
| 2015 | Wet Hot American Summer: First Day of CampSeries | Courtney | 42 |
| 2015 | Nasty BabyMovie | Polly | 42 |
| 2015 | A Deadly AdoptionMovie | Sarah Benson | 42 |
| 2015 | The Heyday of the Insensitive BastardsMovie | Monica | 42 |
| 2014 | How to Train Your Dragon 2Movie | Ruffnut (voice) | 41 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self | 41 |
| 2014 | Variety Studio: Actors on ActorsSeries | Self | 41 |
| 2014 | Late Night with Seth MeyersSeries | Self - Guest | 41 |
| 2014 | The Spoils of BabylonSeries | Cynthia Morehouse | 41 |
| 2014 | The Skeleton TwinsMovie | Maggie Dean | 41 |
| 2014 | Hateship LoveshipMovie | Johanna Parry | 41 |
| 2013 | The Secret Life of Walter MittyMovie | Cheryl Melhoff | 40 |
| 2013 | HerMovie | SexyKitten (voice) | 40 |
| 2013 | Circus HalligalliSeries | Self | 40 |
| 2013 | Drunk HistorySeries | Patty Hearst | 40 |
| 2013 | Anchorman 2: The Legend ContinuesMovie | Chani Lastnamé | 40 |
| 2013 | Despicable Me 2Movie | Lucy (voice) | 40 |
| 2012 | Friends with KidsMovie | Missy | 39 |
| 2012 | Girl Most LikelyMovie | Imogene | 39 |
| 2012 | Comedians in Cars Getting CoffeeSeries | Self | 39 |
| 2012 | Revenge for Jolly!Movie | Angela | 39 |
| 2011 | PortlandiaSeries | Gathy | 38 |
| 2011 | The Looney Tunes ShowSeries | Lola Bunny (voice) | 38 |
| 2011 | Dragons: Gift of the Night FuryMovie | Ruffnut (voice) | 38 |
| 2011 | PaulMovie | Ruth Buggs | 38 |
| 2011 | BridesmaidsMovie | Annie | 38 |
| 2010 | How to Train Your DragonMovie | Ruffnut (voice) | 37 |
| 2010 | MacGruberMovie | Vicki | 37 |
| 2010 | All Good ThingsMovie | Lauren Fleck | 37 |
| 2010 | Ugly AmericansSeries | Tristan (voice) | 37 |
| 2010 | The Women of SNLMovie | Various (archive footage) | 37 |
| 2010 | Legend of the BoneKnapper DragonMovie | Ruffnut Thorston (voice) | 37 |
| 2010 | Date NightMovie | Haley Sullivan | 37 |
| 2010 | Despicable MeMovie | Miss Hattie (voice) | 37 |
| 2010 | Funny or Die PresentsSeries | Loretta | 37 |
| 2009 | Whip ItMovie | Maggie Mayhem | 36 |
| 2009 | The Cleveland ShowSeries | — | 36 |
| 2009 | Ice Age: Dawn of the DinosaursMovie | Pudgy Beaver Mom (voice) | 36 |
| 2009 | Watch What Happens Live with Andy CohenSeries | Self - Guest | 36 |
| 2009 | AdventurelandMovie | Paulette | 36 |
| 2009 | Late Night with Jimmy FallonSeries | Self - Guest | 36 |
| 2009 | ExtractMovie | Suzie | 36 |
| 2008 | Saturday Night Live Weekend Update ThursdaySeries | — | 35 |
| 2008 | Forgetting Sarah MarshallMovie | Yoga Instructor | 35 |
| 2008 | Ghost TownMovie | Surgeon | 35 |
| 2008 | Semi-ProMovie | Bear Handler | 35 |
| 2007 | Flight of the ConchordsSeries | Brahbrah | 34 |
| 2007 | The Graham Norton ShowSeries | Self | 34 |
| 2007 | Knocked UpMovie | Jill | 34 |
| 2007 | The Brothers SolomonMovie | Janine | 34 |
| 2007 | Walk Hard: The Dewey Cox StoryMovie | Edith | 34 |
| 2007 | Meet BillMovie | Jane Whittman | 34 |
| 2006 | 30 RockSeries | Candace Van Der Shark | 33 |
| 2006 | Unaccompanied MinorsMovie | Carole Malone | 33 |
| 2006 | The Enigma with a StigmaMovie | Tux Shop Employee | 33 |
| 2003 | Arrested DevelopmentSeries | Young Lucille Bluth | 30 |
| 2003 | I'm with HerSeries | Kristy | 30 |
| 1999 | SpongeBob SquarePantsSeries | Madame Hagfish (voice) | 26 |
| 1996 | The Daily ShowSeries | Self | 23 |
| 1995 | The Drew Carey ShowSeries | Sandy | 22 |
| 1993 | RawSeries | Vicki Gloria St. Elmo | 20 |
| 1993 | Late Night with Conan O'BrienSeries | Self - Guest | 20 |
| 1989 | The SimpsonsSeries | Calliope Juniper (voice) | 16 |
| 1981 | Entertainment TonightSeries | Self | 8 |
| 1975 | Saturday Night LiveSeries | Self - Various Characters | 2 |
| 1953 | The OscarsSeries | Self - Presenter | — |