| 2024 | AtrabiliousMovie | Roy Altman | 76 |
| 2022 | SherriSeries | Self - Guest | 74 |
| 2021 | Kamp Koral: SpongeBob's Under YearsSeries | Santa Claus (voice) | 73 |
| 2020 | Have a Good Trip: Adventures in PsychedelicsMovie | Self | 72 |
| 2018 | The Epic Tales of Captain UnderpantsSeries | Ragely J. Snarlingtooth (voice) | 70 |
| 2017 | Imitation GirlMovie | Lew | 69 |
| 2017 | The History of ComedySeries | Self | 69 |
| 2017 | GilbertMovie | Self | 69 |
| 2016 | MadoffSeries | Gregory Perkins | 68 |
| 2016 | Rock DogMovie | Linnux (voice) | 68 |
| 2016 | Crisis in Six ScenesSeries | Al | 68 |
| 2015 | Inside OutMovie | Anger (voice) | 67 |
| 2015 | Riley's First Date?Movie | Anger (voice) | 67 |
| 2015 | Misery Loves ComedyMovie | Self | 67 |
| 2015 | Lewis Black & Friends - A Night to Let Freedom Laugh (Live in Washington D.C.)Movie | Self | 67 |
| 2015 | The Late Show with Stephen ColbertSeries | Self - Guest | 67 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self | 66 |
| 2014 | Late Night with Seth MeyersSeries | Self - Guest | 66 |
| 2014 | Comedy Warriors: Healing Through HumorMovie | Self - Coach | 66 |
| 2013 | The Improv: 50 Years Behind the Brick WallMovie | Self | 65 |
| 2012 | Teenage Mutant Ninja TurtlesSeries | Vic / Spider Bytez (voice) | 64 |
| 2012 | Comedians in Cars Getting CoffeeSeries | Self | 64 |
| 2012 | Gotham Comedy LiveSeries | Self - Host | 64 |
| 2011 | Caris' PeaceMovie | Self | 63 |
| 2011 | Afghan LukeMovie | Lewis Black | 63 |
| 2011 | BrainwaveMovie | — | 63 |
| 2010 | Scooby-Doo! Mystery IncorporatedSeries | Mr. E (voice) | 62 |
| 2010 | Teenage PaparazzoMovie | Self | 62 |
| 2010 | I Am ComicMovie | Self | 62 |
| 2010 | The Green Room with Paul ProvenzaSeries | Self | 62 |
| 2010 | Kathleen Madigan: Gone MadiganMovie | Self | 62 |
| 2010 | RobotomySeries | Gore-Ax | 62 |
| 2009 | Celebrity Ghost StoriesSeries | Self | 61 |
| 2008 | Comedy Central Roast of Bob SagetMovie | Self | 60 |
| 2008 | The Penguins of MadagascarSeries | Dale (voice) | 60 |
| 2008 | History of the JokeMovie | Host | 60 |
| 2007 | The Big Bang TheorySeries | Professor Crawley | 59 |
| 2006 | Man of the YearMovie | Eddie Langston | 58 |
| 2006 | Farce of the PenguinsMovie | Jimmy (voice) | 58 |
| 2006 | Unaccompanied MinorsMovie | Oliver Porter | 58 |
| 2006 | Falling for GraceMovie | Rob York | 58 |
| 2006 | Live at GothamSeries | Self | 58 |
| 2005 | The Late Late Show with Craig FergusonSeries | Self | 57 |
| 2005 | The AristocratsMovie | Self | 57 |
| 2005 | Celebrity MixMovie | Self (archive footage) | 57 |
| 2005 | The Happy ElfMovie | Norbert (voice) | 57 |
| 2003 | Duck DodgersSeries | Manobrain (voice) | 55 |
| 2003 | Real Time with Bill MaherSeries | Self - Guest | 55 |
| 2003 | Comedy Central RoastsSeries | Self | 55 |
| 2003 | 60 Spins Around the SunMovie | Self | 55 |
| 2002 | Lewis Black: Taxed Beyond BeliefMovie | Professor Black | 54 |
| 2000 | Harvey Birdman, Attorney at LawSeries | The Deadly Duplicator (voice) | 52 |
| 1999 | Law & Order: Special Victims UnitSeries | B.J. Cameron | 51 |
| 1999 | SpongeBob SquarePantsSeries | Santa Claus (voice) | 51 |
| 1998 | Comedy Central PresentsSeries | Self | 50 |
| 1997 | The ViewSeries | Self | 49 |
| 1996 | The Daily ShowSeries | Self | 48 |
| 1993 | Homicide: Life on the StreetSeries | Laszlo 'Punchy' DeLeon | 45 |
| 1993 | The Night We Never MetMovie | Marty Holder | 45 |
| 1993 | Joey BreakerMovie | Pete Grimm | 45 |
| 1992 | Mad About YouSeries | Pizza Slice | 44 |
| 1991 | The Hard WayMovie | Banker | 43 |
| 1990 | Law & OrderSeries | Director Franklin Frome | 42 |
| 1990 | Jacob's LadderMovie | Jacob's Doctor | 42 |
| 1987 | The Days and Nights of Molly DoddSeries | Bernie | 39 |
| 1986 | Hannah and Her SistersMovie | Paul | 38 |
| 1979 | CBS News Sunday MorningSeries | Self | 31 |
| 0 | Friend ThingMovie | — | — |
