Filmography81 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | One Last Adventure: The Making of Stranger Things 5Movie | Self - Dr. Kay | 70 |
| 2026 | Trust Me, I'm a DoctorMovie | Ellyn Garafalo | 70 |
| 2025 | OsirisMovie | Anya | 69 |
| 2023 | ArnoldSeries | Self | 67 |
| 2021 | Resident AlienSeries | General Eleanor McCallister | 65 |
| 2020 | Easy Does ItMovie | King George | 64 |
| 2019 | Terminator: Dark FateMovie | Sarah Connor | 63 |
| 2017 | CurvatureMovie | Florence | 61 |
| 2017 | Shoot Me NicelyMovie | Layla | 61 |
| 2016 | Stranger ThingsSeries | Dr. Kay | 60 |
| 2015 | The Late Late Show with James CordenSeries | Self | 59 |
| 2013 | Alistair MacLean's Air Force One Is DownSeries | President Harriet Rowntree | 57 |
| 2013 | Bad BehaviorMovie | Margaret | 57 |
| 2012 | Final Cut: Ladies and GentlemenMovie | (archive footage) | 56 |
| 2010 | DC Showcase: Jonah HexMovie | Madame Lorraine (voice) | 54 |
| 2010 | DC Showcase Original Shorts CollectionMovie | Madame Lorraine (segment "Jonah Hex") (voice) | 54 |
| 2010 | RefugeMovie | Amelia Philips | 54 |
| 2009 | Terminator SalvationMovie | Sarah Connor (voice) (uncredited) | 53 |
| 2009 | Terminator SalvationMovie | Sarah Connor (voice over) (uncredited) | 53 |
| 2009 | Holy WaterMovie | Cory Williams | 53 |
| 2009 | A Call to ArmsMovie | Self (voice) | 53 |
| 2009 | The LineSeries | Carol | 53 |
| 2009 | In Your DreamsMovie | Georgie | 53 |
| 2007 | ChuckSeries | Mary Elizabeth Bartowski | 51 |
| 2007 | The Graham Norton ShowSeries | Self | 51 |
| 2007 | BrokenMovie | Karen | 51 |
| 2005 | WeedsSeries | Linda | 49 |
| 2005 | SmileMovie | Bridgette | 49 |
| 2005 | The Kid & IMovie | Susan Mandeville | 49 |
| 2004 | Harvesting Horror: Children of the CornMovie | (archival footage) | 48 |
| 2003 | Jimmy Kimmel Live!Series | Self - Guest | 47 |
| 2002 | Silent NightMovie | Elisabeth Vincken | 46 |
| 2001 | According to JimSeries | Melissa Evans | 45 |
| 2001 | Bailey's MistakeMovie | Liz Donovan | 45 |
| 2001 | Skeletons in the ClosetMovie | Tina | 45 |
| 2001 | A Girl ThingSeries | Rachel Logan | 45 |
| 2000 | Buzz Lightyear of Star CommandSeries | Dr. Furbanna (voice) | 44 |
| 2000 | Sex & Mrs. XMovie | Joanna Scott | 44 |
| 1999 | Batman BeyondSeries | Dr. Stephanie Lake (voice) | 43 |
| 1999 | Batman Beyond: The MovieMovie | Dr. Stephanie Lake (voice) | 43 |
| 1999 | The Color of CourageMovie | Anna Sipes | 43 |
| 1998 | So Graham NortonSeries | Self | 42 |
| 1998 | Getting Close to the ShowMovie | Self | 42 |
| 1998 | On the LineMovie | Jean Martin | 42 |
| 1998 | Point Last SeenMovie | Rachel Myles | 42 |
| 1998 | HerculesSeries | Nemesis (voice) | 42 |
| 1997 | The ViewSeries | Self | 41 |
| 1997 | Shadow ConspiracyMovie | Amanda Givens | 41 |
| 1997 | The New Batman AdventuresSeries | Susan Maguire (voice) | 41 |
| 1997 | Dante's PeakMovie | Rachel Wando | 41 |
| 1995 | Separate LivesMovie | Lauren Porter / Lena | 39 |
| 1995 | The Way to Dusty DeathMovie | Beth MacAlpine | 39 |
| 1995 | A Mother's PrayerMovie | Rosemary Holmstrom | 39 |
| 1993 | FrasierSeries | Claire (voice) | 37 |
| 1993 | FrasierSeries | Laura | 37 |
| 1993 | T2: More Than Meets the EyeMovie | Self | 37 |
| 1991 | Terminator 2: Judgment DayMovie | Sarah Connor | 35 |
| 1991 | The Making of 'Terminator 2: Judgment Day'Movie | Self | 35 |
| 1990 | Mr. DestinyMovie | Ellen Burrows | 34 |
| 1990 | Romy AwardSeries | Self | 34 |
| 1988 | Go Toward the LightMovie | Claire Madison | 32 |
| 1987 | Beauty and the BeastSeries | Catherine Chandler | 31 |
| 1986 | Black Moon RisingMovie | Nina | 30 |
| 1986 | King Kong LivesMovie | Amy Franklin | 30 |
| 1986 | King Kong! The Living LegendMovie | Self | 30 |
| 1985 | The Making of the TerminatorMovie | Self | 29 |
| 1984 | The TerminatorMovie | Sarah Connor | 28 |
| 1984 | Murder, She WroteSeries | Carol McDermott | 28 |
| 1984 | Children of the CornMovie | Vicky | 28 |
| 1984 | The Stone BoyMovie | Eva Crescent Moon Lady | 28 |
| 1983 | WishmanMovie | Mattie MacGregor | 27 |
| 1982 | Late Night with David LettermanSeries | Self | 26 |
| 1982 | Tag: The Assassination GameMovie | Susan Swayze | 26 |
| 1982 | Country GoldMovie | Josie Greenwood | 26 |
| 1982 | King's CrossingSeries | Lauren Hollister | 26 |
| 1980 | ReunionMovie | Anne Samoorian | 24 |
| 1980 | Secrets of Midland HeightsSeries | Lisa Rogers | 24 |
| 1979 | Night-FlowersMovie | Wafer | 23 |
| 1979 | ShirleySeries | — | 23 |
| 1975 | Saturday Night LiveSeries | Self - Host | 19 |
| 0 | Hot CurlersMovie | — | — |