| 2024 | Stand-Up: The Laughing TherapySeries | Self (archive footage) | 57 |
| 2024 | Sorry/Not SorryMovie | Self (archive footage) (uncredited) | 57 |
| 2022 | Fourth of JulyMovie | Therapist | 55 |
| 2020 | The Comedy StoreSeries | Self | 53 |
| 2017 | I Love You, DaddyMovie | Glen Topher | 50 |
| 2017 | Oh, Rick!Movie | Self | 50 |
| 2017 | Night of Too Many Stars: America Unites for Autism ProgramsMovie | Self | 50 |
| 2017 | Jim Norton: Mouthful of ShameMovie | Self (uncredited) | 50 |
| 2017 | Louis C.K. 2017Movie | Self | 50 |
| 2017 | Too Funny to Fail: The Life & Death of The Dana Carvey ShowMovie | Self (archive footage) | 50 |
| 2016 | Horace and PeteSeries | Horace | 49 |
| 2016 | The Secret Life of PetsMovie | Max (voice) | 49 |
| 2016 | The Last LaughMovie | Self (archive footage) (uncredited) | 49 |
| 2015 | TrumboMovie | Arlen Hird | 48 |
| 2015 | Thank You, Del: The Story of the Del Close MarathonMovie | Self | 48 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self | 47 |
| 2014 | Late Night with Seth MeyersSeries | Self | 47 |
| 2014 | The Angriest Man in BrooklynMovie | Dr. Fielding | 47 |
| 2013 | American HustleMovie | Stoddard Thorsen | 46 |
| 2013 | MaronSeries | Himself | 46 |
| 2013 | TunaMovie | Clint | 46 |
| 2013 | Louis C.K.: Oh My GodMovie | Self | 46 |
| 2012 | Gravity FallsSeries | The Horrifying Sweaty One-Armed Monstrosity (voice) | 45 |
| 2012 | Comedians in Cars Getting CoffeeSeries | Self | 45 |
| 2012 | Inside ComedySeries | Self | 45 |
| 2011 | PortlandiaSeries | Louis C.K. | 44 |
| 2011 | Talking FunnyMovie | Self | 44 |
| 2011 | Louis C.K.: Live at the Beacon TheaterMovie | Himself | 44 |
| 2010 | I Am ComicMovie | Self | 43 |
| 2010 | LouieSeries | Louie | 43 |
| 2010 | ConanSeries | Self | 43 |
| 2010 | Louis C.K.: HilariousMovie | Himself | 43 |
| 2010 | This Side of the Truth, A Truly 'Honest' Making of The Invention of LyingMovie | Self | 43 |
| 2009 | Parks and RecreationSeries | Dave Sanderson | 42 |
| 2009 | The Invention of LyingMovie | Greg Kleinschmidt | 42 |
| 2009 | The Tonight Show with Conan O'BrienSeries | Self - Comedian | 42 |
| 2009 | Prequel: The Dawn of LyingMovie | Greg | 42 |
| 2008 | Diminished CapacityMovie | Stan | 41 |
| 2008 | Between Two Ferns with Zach GalifianakisSeries | Self | 41 |
| 2008 | Welcome Home Roscoe JenkinsMovie | Marty | 41 |
| 2008 | Louis C.K.: Chewed UpMovie | Himself | 41 |
| 2007 | Assume the Position 201 with Mr. WuhlMovie | Self | 40 |
| 2006 | Talkshow with Spike FerestenSeries | — | 39 |
| 2006 | Maxed OutMovie | Self | 39 |
| 2006 | Lucky LouieSeries | Louie | 39 |
| 2005 | LondonMovie | Therapist | 38 |
| 2003 | Jimmy Kimmel Live!Series | Self | 36 |
| 2003 | Real Time with Bill MaherSeries | Self | 36 |
| 1999 | Home MoviesSeries | — | 32 |
| 1998 | Comedy Central PresentsSeries | — | 31 |
| 1998 | Tomorrow NightMovie | Man Squirting People With Hose | 31 |
| 1997 | The Chris Rock ShowSeries | — | 30 |
| 1996 | The Daily ShowSeries | Self | 29 |
| 1996 | Pulp ComicsSeries | himself | 29 |
| 1995 | Dr. Katz, Professional TherapistSeries | Louis (voice) | 28 |
| 1993 | Late Show with David LettermanSeries | Self - Guest | 26 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 25 |
| 1990 | Caesar's SaladMovie | UPS Man/Cake Sitter | 23 |
| 1975 | Saturday Night LiveSeries | Self - Host | 8 |
