Filmography99 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | F Valentine's DayMovie | Wendy | 62 |
| 2026 | You're Dating a Narcissist!Movie | Judy | 62 |
| 2026 | Spider-Man: Brand New DayMovie | May Parker | 62 |
| 2024 | UpgradedMovie | Claire | 60 |
| 2024 | BrothersMovie | Bethesda Waingro | 60 |
| 2024 | High TideMovie | Miriam | 60 |
| 2023 | Carol Burnett: 90 Years of Laughter + LoveMovie | Self - Guest | 59 |
| 2022 | Spider-Man: All Roads Lead to No Way HomeMovie | Self (archive footage) | 58 |
| 2021 | Spider-Man: No Way HomeMovie | May Parker | 57 |
| 2021 | Quentin Tarantino: From a Movie Buff to a Hollywood LegendMovie | Self (archive footage) | 57 |
| 2020 | Stars in the HouseSeries | Self | 56 |
| 2020 | Sarah Cooper: Everything's FineMovie | Satan | 56 |
| 2020 | The King of Staten IslandMovie | Margie Carlin | 56 |
| 2019 | Avengers: EndgameMovie | Aunt May | 55 |
| 2019 | Spider-Man: Far From HomeMovie | May Parker | 55 |
| 2019 | Live in Front of a Studio Audience: Norman Lear's "All in the Family" and "The Jeffersons"Movie | Edith Bunker | 55 |
| 2019 | This Changes EverythingMovie | Self | 55 |
| 2019 | I Hate KidsMovie | Christine Hurley | 55 |
| 2019 | FrankieMovie | Ilene | 55 |
| 2018 | The First PurgeMovie | Dr. May Updale / Architect | 54 |
| 2018 | After EverythingMovie | Dr. Lisa Harden | 54 |
| 2018 | Laboratory ConditionsMovie | Emma Holloway | 54 |
| 2017 | Spider-Man: HomecomingMovie | May Parker | 53 |
| 2016 | Captain America: Civil WarMovie | May Parker | 52 |
| 2015 | The Big ShortMovie | Cynthia Baum | 51 |
| 2015 | EmpireSeries | Mimi Whiteman | 51 |
| 2015 | TrainwreckMovie | The Dog Owner | 51 |
| 2015 | Spare PartsMovie | Gwen Kolinsky | 51 |
| 2015 | Love the CoopersMovie | Emma Newport | 51 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self | 50 |
| 2014 | Late Night with Seth MeyersSeries | Self | 50 |
| 2014 | Love Is StrangeMovie | Kate | 50 |
| 2014 | The RewriteMovie | Holly Carpenter | 50 |
| 2014 | Loitering with IntentMovie | Gigi | 50 |
| 2013 | Love, MarilynMovie | Self | 49 |
| 2012 | Finding Your RootsSeries | Self | 48 |
| 2012 | Parental GuidanceMovie | Alice Simmons | 48 |
| 2011 | Crazy, Stupid, Love.Movie | Kate | 47 |
| 2011 | The Lincoln LawyerMovie | Maggie McPherson | 47 |
| 2011 | The Ides of MarchMovie | Ida Horowicz | 47 |
| 2011 | Salvation BoulevardMovie | Honey Foster | 47 |
| 2010 | Who Do You Think You Are?Series | Self | 46 |
| 2010 | CyrusMovie | Molly Fawcett | 46 |
| 2009 | Watch What Happens Live with Andy CohenSeries | Self - Guest | 45 |
| 2009 | We Are One: The Obama Inaugural Celebration at the Lincoln MemorialMovie | Self | 45 |
| 2008 | The WrestlerMovie | Cassidy | 44 |
| 2008 | Directed by Sidney Lumet: How the Devil Was MadeMovie | Self | 44 |
| 2007 | Before the Devil Knows You're DeadMovie | Gina Hanson | 43 |
| 2007 | Wild HogsMovie | Maggie | 43 |
| 2007 | Grace Is GoneMovie | Woman at Pool | 43 |
| 2006 | Marilyn Hotchkiss' Ballroom Dancing & Charm SchoolMovie | Meredith Morrison | 42 |
| 2005 | The Reichen ShowSeries | Self - Guest | 41 |
| 2005 | LoverboyMovie | Sybil | 41 |
| 2005 | FactotumMovie | Laura | 41 |
| 2004 | Rescue MeSeries | Angie | 40 |
| 2004 | AlfieMovie | Julie | 40 |
| 2004 | Cabin Fever: Beneath the SkinMovie | Herself - Guest (uncredited) | 40 |
| 2003 | Anger ManagementMovie | Linda | 39 |
| 2003 | Jimmy Kimmel Live!Series | Self - Guest | 39 |
| 2003 | What I Want My Words to Do to YouMovie | Self | 39 |
| 2002 | The GuruMovie | Lexi | 38 |
| 2002 | The Wild Thornberrys MovieMovie | Bree Blackburn (voice) | 38 |
| 2002 | Just a KissMovie | Paula | 38 |
| 2001 | JeniferMovie | Nina Capelli | 37 |
| 2001 | In the BedroomMovie | Natalie Strout | 37 |
| 2000 | What Women WantMovie | Lola | 36 |
| 2000 | Happy AccidentsMovie | Ruby Weaver | 36 |
| 2000 | The WatcherMovie | Dr. Polly Beilman | 36 |
| 2000 | King of the JungleMovie | Det. Costello | 36 |
| 1999 | Teen Choice AwardsSeries | Self | 35 |
| 1998 | My Own CountryMovie | Mattie Vines | 34 |
| 1998 | Since You've Been GoneMovie | Tori (uncredited) | 34 |
| 1998 | Slums of Beverly HillsMovie | Rita Abromowitz | 34 |
| 1997 | The ViewSeries | Self | 33 |
| 1997 | Welcome to SarajevoMovie | Nina | 33 |
| 1996 | The Daily ShowSeries | Self | 32 |
| 1996 | Unhook the StarsMovie | Monica | 32 |
| 1995 | Four RoomsMovie | Margaret | 31 |
| 1995 | The Perez FamilyMovie | Dottie Perez | 31 |
| 1994 | The PaperMovie | Martha Hackett | 30 |
| 1994 | Only YouMovie | Faith Corvatch | 30 |
| 1993 | Sesame Street's 25th Birthday: A Musical CelebrationMovie | Self (segment "New Way to Walk") | 29 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 28 |
| 1992 | ChaplinMovie | Mabel Normand | 28 |
| 1992 | EquinoxMovie | Rosie Rivers | 28 |
| 1992 | My Cousin VinnyMovie | Mona Lisa Vito | 28 |
| 1991 | OscarMovie | Lisa Provolone | 27 |
| 1991 | ZandaleeMovie | Remy | 27 |
| 1989 | The SimpsonsSeries | Sara Sloane (voice) | 25 |
| 1989 | SeinfeldSeries | Marisa Tomei | 25 |
| 1988 | LIVE with Kelly and MarkSeries | Self | 24 |
| 1987 | A Different WorldSeries | Maggie Lauten | 23 |
| 1987 | Leg WorkSeries | Donna Ricci | 23 |
| 1987 | Supermom's DaughterMovie | Noelle Crandall | 23 |
| 1986 | Playing for KeepsMovie | Tracy | 22 |
| 1984 | The Flamingo KidMovie | Mandy | 20 |
| 1982 | Late Night with David LettermanSeries | Self | 18 |
| 1975 | Saturday Night LiveSeries | Self - Host | 11 |
| 1953 | The OscarsSeries | Self | — |