Filmography66 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2027 | A Place in HellMovie | — | 47 |
| 2025 | Dying for SexSeries | Molly Kochan | 45 |
| 2023 | Off Script with The Hollywood ReporterSeries | Self | 43 |
| 2023 | The Fabelmans: A Family in FilmMovie | Self | 43 |
| 2022 | The FabelmansMovie | Mitzi Fabelman | 42 |
| 2021 | Venom: Let There Be CarnageMovie | Anne Weying | 41 |
| 2019 | Fosse/VerdonSeries | Gwen Verdon | 39 |
| 2019 | The Kelly Clarkson ShowSeries | Self | 39 |
| 2019 | After the WeddingMovie | Isabel | 39 |
| 2019 | That ClickMovie | Self | 39 |
| 2018 | VenomMovie | Anne Weying | 38 |
| 2018 | I Feel PrettyMovie | Avery LeClair | 38 |
| 2017 | The Greatest ShowmanMovie | Charity Barnum | 37 |
| 2017 | All the Money in the WorldMovie | Gail Harris | 37 |
| 2015 | The Late Show with Stephen ColbertSeries | — | 35 |
| 2015 | Close Up with The Hollywood ReporterSeries | Self | 35 |
| 2015 | Suite FrançaiseMovie | Lucille Angellier | 35 |
| 2014 | Variety Studio: Actors on ActorsSeries | Self | 34 |
| 2013 | Letters to Jackie: Remembering President KennedyMovie | Self - Letter Reader | 33 |
| 2013 | Oz the Great and PowerfulMovie | Annie / Glinda | 33 |
| 2012 | Ben Lee: Catch My DiseaseMovie | Self | 32 |
| 2011 | My Week with MarilynMovie | Marilyn Monroe | 31 |
| 2011 | Meek's CutoffMovie | Emily Tetherow | 31 |
| 2010 | Shutter IslandMovie | Dolores | 30 |
| 2010 | Blue ValentineMovie | Cindy | 30 |
| 2009 | Cougar TownSeries | Laurie's Foster Sister | 29 |
| 2009 | Watch What Happens Live with Andy CohenSeries | Self - Guest | 29 |
| 2009 | Late Night with Jimmy FallonSeries | Self - Guest | 29 |
| 2009 | MammothMovie | Ellen Vidales | 29 |
| 2009 | Heath Ledger: A TributeMovie | Self | 29 |
| 2008 | Synecdoche, New YorkMovie | Claire Keen | 28 |
| 2008 | DeceptionMovie | S | 28 |
| 2008 | Wendy and LucyMovie | Wendy Carroll | 28 |
| 2007 | The Graham Norton ShowSeries | Self | 27 |
| 2007 | The Hottest StateMovie | Samantha | 27 |
| 2005 | Brokeback MountainMovie | Alma Beers | 25 |
| 2004 | Land of PlentyMovie | Lana | 24 |
| 2004 | A Hole in OneMovie | Anna Watson | 24 |
| 2003 | Jimmy Kimmel Live!Series | Self | 23 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 23 |
| 2003 | The Station AgentMovie | Emily | 23 |
| 2003 | The United States of LelandMovie | Julie Pollard | 23 |
| 2001 | PerfumeMovie | Halley | 21 |
| 2001 | Me Without YouMovie | Holly | 21 |
| 2000 | If These Walls Could Talk 2Movie | Linda | 20 |
| 2000 | But I'm a CheerleaderMovie | Kimberly | 20 |
| 1999 | DickMovie | Arlene Lorenzo | 19 |
| 1998 | Dawson's CreekSeries | Jen Lindley | 18 |
| 1998 | Halloween H20: 20 Years LaterMovie | Molly Cartwell | 18 |
| 1998 | Unmasking the HorrorMovie | Self | 18 |
| 1997 | The ViewSeries | Self | 17 |
| 1997 | A Thousand AcresMovie | Pammy | 17 |
| 1997 | Killing Mr. GriffinMovie | Maya | 17 |
| 1996 | E! True Hollywood StorySeries | Self (archive footage) | 16 |
| 1996 | My Son Is InnocentMovie | Donna | 16 |
| 1995 | SpeciesMovie | Young Sil | 15 |
| 1995 | TimemasterMovie | Annie | 15 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 12 |
| 1991 | Step by StepSeries | J.J. | 11 |
| 1991 | Home ImprovementSeries | Jessica Lutz | 11 |
| 1989 | BaywatchSeries | — | 9 |
| 1988 | LIVE with Kelly and MarkSeries | Self - Guest | 8 |
| 1953 | The OscarsSeries | Self | — |
| 1949 | The Emmy AwardsSeries | Self | — |
| 0 | Untitled Damien Chazelle FilmMovie | — | — |
| 0 | Jodi Lyn O'Keefe: A Life on ScreenMovie | Self (archive footage) | — |