Filmography73 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | Memory of a KillerSeries | Angelo Doyle | 60 |
| 2025 | Destined to Drive: Patrick Dempsey's Return to RacingMovie | Self | 59 |
| 2024 | Dexter: Original SinSeries | Aaron Spencer | 58 |
| 2023 | FerrariMovie | Piero Taruffi | 57 |
| 2023 | Disney 100: Remember ThatMovie | Self | 57 |
| 2023 | ThanksgivingMovie | Sheriff Eric Newlon | 57 |
| 2023 | Racing With Giants: Porsche at Le MansMovie | Self | 57 |
| 2021 | SurrealEstateSeries | Tom Quincy | 55 |
| 2021 | AluminationMovie | Self | 55 |
| 2020 | DevilsSeries | Dominic Morgan | 54 |
| 2019 | HurleyMovie | Self | 53 |
| 2018 | The Truth About the Harry Quebert AffairSeries | Harry Quebert | 52 |
| 2015 | Jay Leno's GarageSeries | Self | 49 |
| 2015 | Winning: The Racing Life of Paul NewmanMovie | Self | 49 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self - Guest | 48 |
| 2014 | Car Matchmaker with Spike FerestenSeries | Self | 48 |
| 2013 | Ushi Must MarryMovie | Self | 47 |
| 2011 | The Jonathan Ross ShowSeries | Self | 45 |
| 2011 | Transformers: Dark of the MoonMovie | Dylan | 45 |
| 2011 | Boys of BonnevilleMovie | Narrator (voice) | 45 |
| 2010 | Valentine's DayMovie | Dr. Harrison Copeland | 44 |
| 2007 | Private PracticeSeries | Dr. Derek Shepherd | 41 |
| 2007 | EnchantedMovie | Robert Philip | 41 |
| 2007 | Freedom WritersMovie | Scott Casey | 41 |
| 2006 | Brother Bear 2Movie | Kenai (voice) | 40 |
| 2005 | Grey's AnatomySeries | Derek Shepherd | 39 |
| 2005 | The Reichen ShowSeries | Self | 39 |
| 2004 | The Tony Danza ShowSeries | Self - Guest | 38 |
| 2003 | Jimmy Kimmel Live!Series | Self | 37 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 37 |
| 2003 | Karen SiscoSeries | — | 37 |
| 2003 | Lucky 7Movie | Peter Connor | 37 |
| 2002 | Sweet Home AlabamaMovie | Andrew Hennings | 36 |
| 2002 | The Emperor's ClubMovie | Older Louis Masoudi | 36 |
| 2002 | The Caroline Rhea ShowSeries | — | 36 |
| 2002 | Top GearSeries | Self | 36 |
| 2001 | BlondeSeries | Cass | 35 |
| 2001 | Revealed with Jules AsnerSeries | — | 35 |
| 1999 | Family GuySeries | Patrick Dempsey (voice) | 33 |
| 1999 | Family GuySeries | (voice) | 33 |
| 1999 | Me and WillMovie | Fast Eddie | 33 |
| 1998 | Will & GraceSeries | Matthew | 32 |
| 1998 | The EscapeMovie | Clayton | 32 |
| 1998 | DenialMovie | Sam | 32 |
| 1998 | The TreatMovie | Mike | 32 |
| 1998 | Crime and PunishmentMovie | Rodya Raskolnikov | 32 |
| 1998 | Ava's Magical AdventureMovie | Jeffrey | 32 |
| 1997 | The PracticeSeries | Dr. Paul Stewart | 31 |
| 1997 | The ViewSeries | Self | 31 |
| 1997 | 20,000 Leagues Under the SeaSeries | Pierre Arronax | 31 |
| 1997 | Hugo PoolMovie | Floyd Gaylen | 31 |
| 1996 | The Daily ShowSeries | Self | 30 |
| 1996 | E! True Hollywood StorySeries | — | 30 |
| 1995 | OutbreakMovie | Jimbo Scott | 29 |
| 1994 | With HonorsMovie | Everett Calloway | 28 |
| 1993 | Bank RobberMovie | Billy | 27 |
| 1993 | For Better and for WorseMovie | Robert Faldo | 27 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 26 |
| 1991 | MobstersMovie | Meyer Lansky | 25 |
| 1991 | RunMovie | Charlie Farrow | 25 |
| 1990 | The WordSeries | — | 24 |
| 1989 | LoverboyMovie | Randy Bodek | 23 |
| 1989 | Happy TogetherMovie | Chris Wooden | 23 |
| 1988 | LIVE with Kelly and MarkSeries | Self - Guest | 22 |
| 1988 | Some GirlsMovie | Michael | 22 |
| 1987 | In the MoodMovie | Ellsworth "Sonny" Wisecarver | 21 |
| 1987 | Can't Buy Me LoveMovie | Ronald Miller | 21 |
| 1986 | A Fighting ChoiceMovie | Kellin Taylor | 20 |
| 1985 | The StuffMovie | Underground Stuff Buyer (uncredited) | 19 |
| 1985 | Heaven Help UsMovie | Corbet | 19 |
| 1982 | Late Night with David LettermanSeries | Self | 16 |
| 1981 | Entertainment TonightSeries | — | 15 |
| 1953 | The OscarsSeries | Self | — |