| 2025 | Marty SupremeMovie | Hoff | 70 |
| 2025 | WWE NXT Stand & Deliver 2025Movie | Penn | 70 |
| 2024 | After MidnightSeries | Self | 69 |
| 2022 | The G Word with Adam ConoverSeries | Self | 67 |
| 2021 | Celebrity Wheel of FortuneSeries | Self - Contestant | 66 |
| 2021 | Bob Dylan: Odds and EndsMovie | Self - Narrator | 66 |
| 2020 | I Can See Your VoiceSeries | — | 65 |
| 2020 | The Choice 2020: Trump vs. BidenMovie | Self - Interviewee | 65 |
| 2019 | The Masked SingerSeries | Hydra | 64 |
| 2019 | Rob & Romesh VsSeries | Self | 64 |
| 2019 | Scooby-Doo and Guess Who?Series | Penn Jillette (voice) | 64 |
| 2019 | J.R. “Bob” Dobbs and The Church of the SubGeniusMovie | Self | 64 |
| 2018 | 25 Words or LessSeries | Self | 63 |
| 2018 | Always AmazingMovie | Self | 63 |
| 2018 | Morecambe & Wise in AmericaSeries | Self | 63 |
| 2018 | Gambler's Ballad: The Legend of Johnny ThompsonMovie | Self | 63 |
| 2017 | Young SheldonSeries | A.V. | 62 |
| 2017 | Sandy WexlerMovie | Testimonial | 62 |
| 2017 | GilbertMovie | Self | 62 |
| 2016 | BillionsSeries | Penn Jillette | 61 |
| 2016 | The Grand TourSeries | Self | 61 |
| 2016 | Director's CutMovie | Herbert Blount | 61 |
| 2016 | Eating You AliveMovie | Self | 61 |
| 2016 | Can We Take a Joke?Movie | Self | 61 |
| 2016 | Unlocked: The World of Games, RevealedSeries | Self | 61 |
| 2015 | Sharknado 3: Oh Hell No!Movie | Lieutenant Colonel Stylo | 60 |
| 2015 | Code BlackSeries | Johnny Prentiss | 60 |
| 2015 | Misery Loves ComedyMovie | Self | 60 |
| 2015 | StarTalk with Neil deGrasse TysonSeries | Self | 60 |
| 2015 | Theory of Obscurity: A Film About the ResidentsMovie | Himself | 60 |
| 2015 | The Keyboard Cowboys: A Look Back at HackersMovie | — | 60 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self | 59 |
| 2014 | ScorpionSeries | Dr. Cecil P. Rizzuto | 59 |
| 2014 | Good Morning BritainSeries | Self | 59 |
| 2014 | An Honest LiarMovie | Self | 59 |
| 2013 | The Arsenio Hall ShowSeries | Self | 58 |
| 2013 | Through the KeyholeSeries | Self | 58 |
| 2013 | The UnbelieversMovie | Self | 58 |
| 2013 | Beat Bobby FlaySeries | Self | 58 |
| 2013 | Have You Been Paying Attention?Series | Self - Guest Quizmaster | 58 |
| 2013 | Whose Line Is It Anyway?Series | Self | 58 |
| 2013 | Alpha HouseSeries | Penn Jillette | 58 |
| 2013 | Anthony Bourdain: Parts UnknownSeries | Self | 58 |
| 2013 | Deal With ItSeries | Self | 58 |
| 2013 | Tim's VermeerMovie | Himself | 58 |
| 2012 | The Eric Andre ShowSeries | Self | 57 |
| 2011 | My Favorite PlaceSeries | Self | 56 |
| 2011 | Night of the Little DeadMovie | Dave-O | 56 |
| 2010 | The DefendersSeries | Reuben Charters | 55 |
| 2010 | Brave New Voices 2010Movie | Himself | 55 |
| 2009 | Modern FamilySeries | Edward LeGrand | 54 |
| 2009 | Futurama: Into the Wild Green YonderMovie | Penn Jillette's Head (voice) | 54 |
| 2008 | Free RadioSeries | Self | 53 |
| 2008 | History of the JokeMovie | Self | 53 |
| 2007 | Mr. Warmth: The Don Rickles ProjectMovie | Self | 52 |
| 2007 | To My Great Chagrin: The Unbelievable Story of Brother TheodoreMovie | Self | 52 |
| 2006 | America's Got TalentSeries | Self - Performer | 51 |
| 2006 | Midnight Blue, Vol. 3: Celebrities EditionMovie | Self (archive footage) | 51 |
| 2005 | Numb3rsSeries | Penn Jillette | 50 |
| 2005 | Dancing with the StarsSeries | Self - Contestant | 50 |
| 2005 | Hell's KitchenSeries | Self | 50 |
| 2005 | The AristocratsMovie | Self | 50 |
| 2005 | Mucha Lucha: The Return of El MaleficoMovie | Fortune Teller / Pawn Shop Owner / Ticket Man (voice) | 50 |
| 2005 | Penn & Teller: Off the Deep EndMovie | Self | 50 |
| 2004 | Listen Up!Series | Penn Jillette | 49 |
| 2004 | My Coolest YearsSeries | Himself | 49 |
| 2004 | Michael Moore Hates AmericaMovie | Self | 49 |
| 2004 | Goodnight, We Love YouMovie | Self | 49 |
| 2003 | Las VegasSeries | Penn Jilette | 48 |
| 2003 | Penn & Teller: Bull!Series | Himself | 48 |
| 2001 | The Bernie Mac ShowSeries | Penn | 46 |
| 2001 | Fear FactorSeries | — | 46 |
| 2001 | Disney's House of MouseSeries | Pluto Devil (voice) | 46 |
| 2000 | GirlfriendsSeries | Clem Valesco | 45 |
| 2000 | Fantasia 2000Movie | Self - Host | 45 |
| 1999 | The West WingSeries | Penn Jilette | 44 |
| 1999 | Mickey Mouse WorksSeries | — | 44 |
| 1998 | V.I.P.Series | Penn Jillette | 43 |
| 1998 | Hollywood SquaresSeries | Self - Panelist | 43 |
| 1998 | Fear and Loathing in Las VegasMovie | Carnie Talker | 43 |
| 1997 | Just Shoot Me!Series | Terry | 42 |
| 1997 | The ViewSeries | Self | 42 |
| 1997 | Dharma & GregSeries | Vincent (uncredited) | 42 |
| 1996 | Sabrina, the Teenage WitchSeries | Drell | 41 |
| 1996 | Muppets TonightSeries | Self | 41 |
| 1996 | Great DrivesSeries | Self | 41 |
| 1995 | The Drew Carey ShowSeries | Archibald Fenn | 40 |
| 1995 | Toy StoryMovie | TV Announcer (voice) | 40 |
| 1995 | HackersMovie | Hal | 40 |
| 1995 | VR.5Series | Mr. Orwell Kravitz | 40 |
| 1995 | Burnzy's Last CallMovie | Radio DJ | 40 |
| 1995 | Phobophilia: The Love of FearMovie | Himself | 40 |
| 1994 | FriendsSeries | Salesman | 39 |
| 1994 | Space Ghost Coast to CoastSeries | Self | 39 |
| 1994 | Babylon 5Series | Rebo | 39 |
| 1994 | The World's Greatest MagicSeries | Self | 39 |
| 1994 | Car 54, Where Are You?Movie | Luther | 39 |
| 1994 | The Steven Banks ShowSeries | Penn Jillette | 39 |
| 1993 | Lois & Clark: The New Adventures of SupermanSeries | Romick | 38 |
| 1993 | Half Japanese: The Band That Would Be KingMovie | Self | 38 |
| 1992 | Behind the ScenesSeries | — | 37 |
| 1991 | Home ImprovementSeries | Penn Jillette | 36 |
| 1990 | The WordSeries | — | 35 |
| 1989 | The SimpsonsSeries | Penn Jilette (voice) | 34 |
| 1989 | Penn & Teller Get KilledMovie | Self | 34 |
| 1989 | Steven Banks: Home Entertainment CenterMovie | pre-show host | 34 |
| 1988 | Free to Be... a FamilyMovie | Self | 33 |
| 1987 | Penn & Teller's Invisible ThreadMovie | Penn | 32 |
| 1987 | Tough Guys Don't DanceMovie | Big Stoop | 32 |
| 1986 | My ChauffeurMovie | Bone | 31 |
| 1986 | Barbecue Death Squad From HellMovie | Himself | 31 |
| 1985 | Savage IslandMovie | Security Guard | 30 |
| 1984 | Miami ViceSeries | Jimmy Borges | 29 |
| 1982 | Late Night with David LettermanSeries | Self - Guest | 27 |
| 1978 | The Magic of David CopperfieldSeries | — | 23 |
| 1975 | Saturday Night LiveSeries | Self | 20 |
| 1961 | The Mike Douglas ShowSeries | Self | 6 |