Filmography39 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2022 | The KardashiansSeries | Self | 49 |
| 2021 | Adele One Night OnlyMovie | Self | 48 |
| 2018 | Ellen DeGeneres: RelatableMovie | Self | 45 |
| 2017 | Santa Clarita DietSeries | Dr. Cora Wolf | 44 |
| 2015 | UnityMovie | Narrator (voice) | 42 |
| 2015 | Tab Hunter ConfidentialMovie | Self | 42 |
| 2013 | Sean Saves the WorldSeries | Jill | 40 |
| 2012 | ScandalSeries | Elizabeth North | 39 |
| 2012 | Mockingbird LaneMovie | Lily Munster | 39 |
| 2005 | CursedMovie | Zela | 32 |
| 2004 | Dead & BreakfastMovie | Kelly - The Bride | 31 |
| 2003 | Arrested DevelopmentSeries | Lindsay Bluth Fünke | 30 |
| 2003 | Nip/TuckSeries | Olivia Lord | 30 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 30 |
| 2003 | The Night We Called It a DayMovie | Hilary Hunter | 30 |
| 2003 | Mister SterlingSeries | Lauren Barnes | 30 |
| 2003 | America's Prince: The John F. Kennedy Jr. StoryMovie | Carolyn Bessette Kennedy | 30 |
| 2003 | I WitnessMovie | Emily Thompson (as Portia De Rossi) | 30 |
| 2002 | The Twilight ZoneSeries | Laurel Janus | 29 |
| 2002 | Live from E!Series | Self | 29 |
| 2002 | The GlowMovie | Jackie Lawrence | 29 |
| 2001 | Who Is Cletis Tout?Movie | Tess Donnelly | 28 |
| 1999 | Family GuySeries | Bonnie Swanson's Prank Call Voice (voice) | 26 |
| 1999 | StigmataMovie | Jennifer Kelliho | 26 |
| 1999 | The InvisiblesMovie | Joy | 26 |
| 1998 | GirlMovie | Carla | 25 |
| 1998 | Perfect AssassinsMovie | Leo Benita | 25 |
| 1997 | Ally McBealSeries | Nelle Porter | 24 |
| 1997 | The ViewSeries | Self | 24 |
| 1997 | Veronica's ClosetSeries | Carolyn | 24 |
| 1997 | Scream 2Movie | Sorority Sister Murphy | 24 |
| 1996 | Nick Freno: Licensed TeacherSeries | Elana Lewis | 23 |
| 1995 | MADtvSeries | Self | 22 |
| 1995 | Too SomethingSeries | Maria Hunter | 22 |
| 1994 | SirensMovie | Giddy | 21 |
| 1993 | Late Night with Conan O'BrienSeries | Self - Guest | 20 |
| 1988 | LIVE with Kelly and MarkSeries | — | 15 |
| 1975 | People's Choice AwardsSeries | Self - Presenter | 2 |
| 0 | The ReceptionMovie | — | — |