Filmography67 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | Avengers: DoomsdayMovie | Raven Darkholme / Mystique | 54 |
| 2022 | PictionarySeries | — | 50 |
| 2022 | Star Trek: Strange New WorldsSeries | Una Chin-Riley | 50 |
| 2022 | The Real Love BoatSeries | Self - Host | 50 |
| 2022 | Sleep No MoreMovie | Miss Ross | 50 |
| 2019 | Batman: HushMovie | Lois Lane (voice) | 47 |
| 2019 | The Ready RoomSeries | Self | 47 |
| 2019 | Satanic PanicMovie | Danica Ross | 47 |
| 2018 | Star Trek: Short TreksSeries | Number One | 46 |
| 2017 | Star Trek: DiscoverySeries | Number One | 45 |
| 2017 | Love LocksMovie | Lindsey Wilson | 45 |
| 2016 | Sports Illustrated Swimsuit 2016 RevealedMovie | Self - Host | 44 |
| 2015 | The Late Late Show with James CordenSeries | Self | 43 |
| 2015 | Larry Gaye: Renegade Male Flight AttendantMovie | Sally the Flightpal | 43 |
| 2014 | Late Night with Seth MeyersSeries | Self | 42 |
| 2014 | The LibrariansSeries | Eve Baird | 42 |
| 2014 | Skin WarsSeries | Self - Host | 42 |
| 2014 | Phantom HaloMovie | Ms. Rose | 42 |
| 2013 | King & MaxwellSeries | Michelle Maxwell | 41 |
| 2013 | Bettie Page Reveals AllMovie | Self | 41 |
| 2012 | Key & PeeleSeries | Pirate Captain | 40 |
| 2011 | NTSF:SD:SUV::Series | Jessie Nichols | 39 |
| 2011 | X-Men: First ClassMovie | Mystique - Older (uncredited) | 39 |
| 2009 | Watch What Happens Live with Andy CohenSeries | Self - Guest | 37 |
| 2009 | InfomercialsSeries | Jessie Nichols | 37 |
| 2009 | RuPaul's Drag RaceSeries | Self - Guest Judge | 37 |
| 2008 | Lake CityMovie | Jennifer | 36 |
| 2007 | ChuckSeries | Robin Cunnings | 35 |
| 2007 | CarpoolersSeries | Joannifer | 35 |
| 2006 | Ugly BettySeries | Alexis Meade | 34 |
| 2006 | X-Men: The Last StandMovie | Raven Darkholme / Mystique | 34 |
| 2006 | Pepper DennisSeries | Pepper Dennis | 34 |
| 2006 | Brett Ratner's X-DiariesMovie | Self | 34 |
| 2004 | The PunisherMovie | Joan | 32 |
| 2004 | Project RunwaySeries | Self - Guest Judge | 32 |
| 2004 | GodsendMovie | Jessie Duncan | 32 |
| 2004 | War Journal: On the Set of The PunisherMovie | Self | 32 |
| 2003 | Jimmy Kimmel Live!Series | Self | 31 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 31 |
| 2003 | Late Night with Conan O'Brien: 10th Anniversary SpecialMovie | Self | 31 |
| 2003 | X2Movie | Raven Darkholme / Mystique | 31 |
| 2003 | Evolution X - The Making of X-MenMovie | — | 31 |
| 2003 | Femme Fatale: Dream Within a DreamMovie | Self | 31 |
| 2003 | X2 Global Webcast HighlightsMovie | Self | 31 |
| 2003 | X-Men: Premieres Around the WorldMovie | Self | 31 |
| 2002 | American IdolSeries | Self | 30 |
| 2002 | Femme FataleMovie | Laure Ash / Lily Watts | 30 |
| 2002 | RollerballMovie | Aurora | 30 |
| 2001 | Once Upon a Time: The Super HeroesMovie | Mystique (archive footage) | 29 |
| 2000 | Curb Your EnthusiasmSeries | Penelope | 28 |
| 2000 | X-MenMovie | Mystique | 28 |
| 2000 | X-Men: The Mutant WatchMovie | Self - 'Mystique' | 28 |
| 1999 | WWE Friday Night SmackDownSeries | Self | 27 |
| 1999 | Jack & JillSeries | — | 27 |
| 1999 | Teen Choice AwardsSeries | Self | 27 |
| 1999 | Austin Powers: The Spy Who Shagged MeMovie | Rebecca Romijn | 27 |
| 1999 | Behind the Scenes of 'Austin Powers: The Spy Who Shagged Me'Movie | Self | 27 |
| 1998 | Dirty WorkMovie | Bearded Lady | 26 |
| 1998 | Sports Illustrated: Swimsuit 1998Movie | Self/Host | 26 |
| 1997 | Just Shoot Me!Series | Adrienne | 25 |
| 1996 | The Daily ShowSeries | Self | 24 |
| 1994 | FriendsSeries | Cheryl | 22 |
| 1994 | Space Ghost Coast to CoastSeries | — | 22 |
| 1994 | Supermodels in the RainforestMovie | Self | 22 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 20 |
| 1992 | MTV Movie & TV AwardsSeries | Self - Presenter | 20 |
| 1988 | LIVE with Kelly and MarkSeries | Self - Guest | 16 |