Filmography103 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2025 | The StudioSeries | Matt's Mom | 77 |
| 2025 | Mid-Century ModernSeries | Judy | 77 |
| 2023 | BarbieMovie | Ruth | 75 |
| 2023 | Poker FaceSeries | Beatrix Hasp | 75 |
| 2023 | You PeopleMovie | Bubby | 75 |
| 2023 | Not Dead YetSeries | Janice | 75 |
| 2022 | 13: The MusicalMovie | Grandma Ruth | 74 |
| 2021 | Star Wars: The Bad BatchSeries | Cid (voice) | 73 |
| 2019 | Harley QuinnSeries | Golda (voice) | 71 |
| 2019 | PomsMovie | Alice | 71 |
| 2018 | The MatchmakerMovie | Irene | 70 |
| 2017 | LemonMovie | Esther | 69 |
| 2017 | Me and My GrandmaSeries | Grandma | 69 |
| 2016 | SingMovie | Judith (voice) | 68 |
| 2016 | ShooterSeries | Supreme Court Justice Gibson | 68 |
| 2016 | Must See TV: An All Star Tribute to James BurrowsMovie | Self | 68 |
| 2015 | I'll See You in My DreamsMovie | Sally | 67 |
| 2014 | Tim and Eric's Bedtime StoriesSeries | Maureen | 66 |
| 2013 | MomSeries | Anya | 65 |
| 2013 | Brooklyn Nine-NineSeries | Estelle | 65 |
| 2013 | The GoldbergsSeries | Margot Letien | 65 |
| 2013 | Getting OnSeries | Crystal Buff | 65 |
| 2012 | The Mindy ProjectSeries | Annette Castellano | 64 |
| 2012 | The SessionsMovie | Mikvah Lady | 64 |
| 2012 | Robot and MonsterSeries | Nessie (voice) | 64 |
| 2011 | WilfredSeries | Mittens | 63 |
| 2011 | The Trouble with BlissMovie | Maria (uncredited) | 63 |
| 2010 | Hot in ClevelandSeries | Jacki | 62 |
| 2009 | Watch What Happens Live with Andy CohenSeries | Self - Guest | 61 |
| 2008 | The Christmas ChoirMovie | Sister Agatha | 60 |
| 2007 | Love Comes LatelyMovie | Reisel | 59 |
| 2006 | The Megan Mullally ShowSeries | Self - Guest | 58 |
| 2006 | CrumbsSeries | Camille Spadaro | 58 |
| 2006 | 10 Items or LessMovie | Mrs. D | 58 |
| 2005 | It's Always Sunny in PhiladelphiaSeries | Bertha Fussy | 57 |
| 2005 | American Dad!Series | Old Stripper (voice) | 57 |
| 2005 | Matilda's Movie Magic: The Making of 'Matilda'Movie | Self | 57 |
| 2005 | My Movie About Making 'Matilda' by Mara WilsonMovie | Self | 57 |
| 2004 | Kevin HillSeries | Eleanor Frank | 56 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 55 |
| 2002 | What's New, Scooby-Doo?Series | Agnes (voice) | 54 |
| 2002 | NBC 75th Anniversary SpecialMovie | Self | 54 |
| 2001 | Kate BrasherSeries | Abbie Schaeffer | 53 |
| 1999 | Law & Order: Special Victims UnitSeries | Roxana Fox | 51 |
| 1999 | The Frasier StoryMovie | Self | 51 |
| 1998 | BeckerSeries | Dr. Katherine Simmons | 50 |
| 1998 | In the DoghouseMovie | Phil Markowitz | 50 |
| 1997 | Ally McBealSeries | Dr. Helen Tooth | 49 |
| 1997 | The ViewSeries | Self | 49 |
| 1997 | Union SquareSeries | Eileen Mulrooney | 49 |
| 1996 | The Rosie O'Donnell ShowSeries | Self - Guest | 48 |
| 1996 | MatildaMovie | Zinnia Wormwood | 48 |
| 1996 | CarpoolMovie | Martha | 48 |
| 1996 | Sunset ParkMovie | Phyllis Saroka | 48 |
| 1996 | PearlSeries | Pearl Caraldo | 48 |
| 1995 | Canadian BaconMovie | Deputy Honey | 47 |
| 1994 | The CriticSeries | Ardeth (voice) | 46 |
| 1994 | The World of Jim HensonMovie | Self (archive footage) | 46 |
| 1994 | Spoils of WarMovie | Emma | 46 |
| 1993 | FrasierSeries | Carla Tortelli | 45 |
| 1993 | We're Back! A Dinosaur's StoryMovie | Mother Bird (voice) | 45 |
| 1993 | A Place to Be LovedMovie | Jerry Blair | 45 |
| 1992 | Mad About YouSeries | Mrs. Ramona DiChristophoro | 44 |
| 1992 | Class ActMovie | Miss Simpson | 44 |
| 1992 | There Goes the NeighborhoodMovie | Lydia Nunn | 44 |
| 1992 | To Grandmother's House We GoMovie | Shirley | 44 |
| 1991 | RocSeries | — | 43 |
| 1991 | Ted & VenusMovie | Grace | 43 |
| 1990 | BlossomSeries | The Godfather | 42 |
| 1990 | The Earth Day SpecialMovie | Paula | 42 |
| 1990 | Enid Is SleepingMovie | Mavis | 42 |
| 1990 | Sesame Street: Sing Yourself Silly!Movie | Self (archive footage) | 42 |
| 1990 | Disneyland's 35th Anniversary CelebrationMovie | Carla Tortelli | 42 |
| 1990 | Amazing Stories: The Movie IIMovie | Lois | 42 |
| 1989 | The SimpsonsSeries | Carla Tortelli (voice) | 41 |
| 1988 | Mickey's 60th BirthdayMovie | Carla Tortelli | 40 |
| 1988 | Sesame Street: Put Down the DuckieMovie | Self | 40 |
| 1988 | A Family AgainMovie | Aunt Dee | 40 |
| 1987 | Stamp of a KillerMovie | Claudia | 39 |
| 1987 | The TortellisSeries | Carla Tortelli | 39 |
| 1987 | Funny, You Don't Look 200: A Constitutional VaudevilleMovie | Maisy - Constitutional Caterer | 39 |
| 1986 | MatlockSeries | Rhea Perlman | 38 |
| 1986 | My Little Pony: The MovieMovie | Reeka (voice) | 38 |
| 1986 | My Little PonySeries | — | 38 |
| 1985 | Amazing StoriesSeries | Lois | 37 |
| 1985 | The NBC All Star Hour: Let's All Be ThereMovie | — | 37 |
| 1985 | Happily Ever AfterMovie | Rose Johnson (voice) | 37 |
| 1984 | The Ratings GameMovie | Francine Kester | 36 |
| 1982 | St. ElsewhereSeries | Carla Tortelli | 34 |
| 1982 | CheersSeries | Carla Tortelli | 34 |
| 1982 | National Lampoon's Movie MadnessMovie | Little Jewish Prostitute ("Municipalians") | 34 |
| 1982 | Drop-Out FatherMovie | Tawney Shapiro | 34 |
| 1982 | Love ChildMovie | June Burns | 34 |
| 1979 | Swap MeetMovie | Mother | 31 |
| 1978 | TaxiSeries | Zena Sherman | 30 |
| 1977 | Intimate StrangersMovie | Barbara | 29 |
| 1977 | Mary Jane Harper Cried Last NightMovie | Judy | 29 |
| 1976 | I Want to Keep My Baby!Movie | Rae Finer | 28 |
| 1976 | Stalk the Wild ChildMovie | Jean | 28 |
| 1976 | The Selling of Vince D'AngeloMovie | Vince's Wife | 28 |
| 1975 | Saturday Night LiveSeries | Self - Co-Host | 27 |
| 1975 | MinestroneMovie | Tessy | 27 |
| 1972 | Hot Dogs for GauguinMovie | Woman on Ferry | 24 |