Filmography132 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2027 | Avengers: Secret WarsMovie | Victor von Doom / Doctor Doom | 62 |
| 2026 | Avengers: DoomsdayMovie | Victor von Doom / Doctor Doom | 61 |
| 2025 | The Fantastic 4: First StepsMovie | Victor von Doom / Doctor Doom (uncredited) | 60 |
| 2024 | The SympathizerSeries | Claude / Professor Hammer / Ned Godwin / Niko Damianos / Priest | 59 |
| 2024 | Disney Legends Award CeremonySeries | Self | 59 |
| 2023 | OppenheimerMovie | Lewis Strauss | 58 |
| 2023 | Off Script with The Hollywood ReporterSeries | Self | 58 |
| 2022 | 2022 Rock & Roll Hall of Fame Induction CeremonyMovie | Self - Presenter | 57 |
| 2022 | "Sr."Movie | Self | 57 |
| 2021 | Marvel Studios LegendsSeries | Tony Stark / Iron Man (archive footage) (uncredited) | 56 |
| 2021 | Marvel Studios AssembledSeries | Tony Stark / Iron Man (archive footage) | 56 |
| 2020 | DolittleMovie | Dr. John Dolittle | 55 |
| 2020 | Chadwick Boseman: A Tribute for a KingMovie | Self | 55 |
| 2020 | MoPOP Founders Award 2020 Honoring Alice in ChainsMovie | Self | 55 |
| 2019 | Avengers: EndgameMovie | Tony Stark / Iron Man | 54 |
| 2019 | Ellen's Greatest Night of GiveawaysSeries | Self | 54 |
| 2019 | The Chef ShowSeries | Self - Guest | 54 |
| 2018 | Avengers: Infinity WarMovie | Tony Stark / Iron Man | 53 |
| 2018 | My Next Guest Needs No Introduction with David LettermanSeries | Self | 53 |
| 2017 | Spider-Man: HomecomingMovie | Tony Stark / Iron Man | 52 |
| 2017 | A Fan's Guide to Spider-Man HomecomingMovie | Self | 52 |
| 2017 | The True Story of...Series | Self (archive footage) | 52 |
| 2016 | Captain America: Civil WarMovie | Tony Stark / Iron Man | 51 |
| 2016 | The Nice GuysMovie | Sid Shattuck (uncredited) | 51 |
| 2016 | WIRED's Autocomplete InterviewsSeries | Self - Guest | 51 |
| 2015 | Avengers: Age of UltronMovie | Tony Stark / Iron Man | 50 |
| 2015 | The Late Show with Stephen ColbertSeries | Self - Guest | 50 |
| 2015 | Phase 2 Tag Scenes: A Making of the Marvel Cinematic Universe Phase TwoMovie | Self | 50 |
| 2014 | ChefMovie | Marvin | 49 |
| 2014 | The Tonight Show Starring Jimmy FallonSeries | Self | 49 |
| 2014 | Variety Studio: Actors on ActorsSeries | Self | 49 |
| 2014 | Late Night with Seth MeyersSeries | Self - Guest | 49 |
| 2014 | Marvel Studios: Assembling a UniverseMovie | Self / Tony Stark / Iron Man | 49 |
| 2014 | Off Camera with Sam JonesSeries | Self | 49 |
| 2014 | The JudgeMovie | Hank Palmer | 49 |
| 2014 | I Am Steve McQueenMovie | Self - Narrator (voice) | 49 |
| 2014 | Marvel: 75 Years, from Pulp to Pop!Movie | Self | 49 |
| 2013 | Iron Man 3Movie | Tony Stark | 48 |
| 2013 | The FrameSeries | Tony Stark / Iron Man | 48 |
| 2012 | The AvengersMovie | Tony Stark / Iron Man | 47 |
| 2012 | Finding Your RootsSeries | Self | 47 |
| 2012 | Marvel Studios: Building a Cinematic UniverseMovie | Self | 47 |
| 2011 | Sherlock Holmes: A Game of ShadowsMovie | Sherlock Holmes | 46 |
| 2011 | Marvel One-Shot: The ConsultantMovie | Tony Stark (archive footage) | 46 |
| 2010 | Iron Man 2Movie | Tony Stark | 45 |
| 2010 | Love and DistrustMovie | Rob (segment "Auto Motives") | 45 |
| 2010 | Due DateMovie | Peter Highman | 45 |
| 2010 | Sherlock Holmes: ReinventedMovie | Self | 45 |
| 2009 | Sherlock HolmesMovie | Sherlock Holmes | 44 |
| 2009 | Live from Studio FiveSeries | Self | 44 |
| 2009 | The SoloistMovie | Steve Lopez | 44 |
| 2008 | Tropic ThunderMovie | Kirk Lazarus | 43 |
| 2008 | Iron ManMovie | Tony Stark | 43 |
| 2008 | The Incredible HulkMovie | Tony Stark (uncredited) | 43 |
| 2008 | Tropic Thunder: Rain of MadnessMovie | Kirk Lazarus | 43 |
| 2008 | Charlie BartlettMovie | Nathan Gardner | 43 |
| 2007 | ZodiacMovie | Paul Avery | 42 |
| 2007 | The Graham Norton ShowSeries | Self | 42 |
| 2007 | Annie Leibovitz: Life Through a LensMovie | Self | 42 |
| 2007 | Lucky YouMovie | Telephone Jack | 42 |
| 2007 | Voom PortraitsMovie | Self | 42 |
| 2006 | Game 6Movie | Steven Schwimmer | 41 |
| 2006 | A Scanner DarklyMovie | James Barris | 41 |
| 2006 | The Shaggy DogMovie | Dr. Kozak | 41 |
| 2006 | A Guide to Recognizing Your SaintsMovie | Dito | 41 |
| 2006 | Fur: An Imaginary Portrait of Diane ArbusMovie | Lionel Sweeney | 41 |
| 2005 | The Reichen ShowSeries | Self | 40 |
| 2005 | The Showbiz Show with David SpadeSeries | — | 40 |
| 2005 | Kiss Kiss Bang BangMovie | Harry Lockhart | 40 |
| 2005 | Good Night, and Good Luck.Movie | Joe Wershba | 40 |
| 2004 | ErosMovie | Nick Penrose | 39 |
| 2003 | GothikaMovie | Pete Graham | 38 |
| 2003 | Jimmy Kimmel Live!Series | Self - Guest | 38 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 38 |
| 2003 | Charlie: The Life and Art of Charles ChaplinMovie | — | 38 |
| 2003 | Punk'dSeries | Self | 38 |
| 2003 | The Singing DetectiveMovie | Dan Dark | 38 |
| 2000 | Wonder BoysMovie | Terry Crabtree | 35 |
| 1999 | Family GuySeries | Patrick Pewterschmidt (voice) | 34 |
| 1999 | The Early ShowSeries | Self | 34 |
| 1999 | Black and WhiteMovie | Terry Donager | 34 |
| 1999 | BowfingerMovie | Jerry Renfro | 34 |
| 1999 | In DreamsMovie | Vivian Thompson | 34 |
| 1998 | U.S. MarshalsMovie | Royce | 33 |
| 1998 | The Gingerbread ManMovie | Clyde Pell | 33 |
| 1998 | Two Girls and a GuyMovie | Blake | 33 |
| 1997 | Ally McBealSeries | Larry Paul | 32 |
| 1997 | The ViewSeries | Self | 32 |
| 1997 | One Night StandMovie | Charlie | 32 |
| 1997 | Hugo PoolMovie | Franz Mazur | 32 |
| 1996 | The Daily ShowSeries | Self - Guest | 31 |
| 1996 | Danger ZoneMovie | Jim Scott | 31 |
| 1995 | The Frank Skinner ShowSeries | Self | 30 |
| 1995 | Richard IIIMovie | Earl Rivers | 30 |
| 1995 | RestorationMovie | Robert Merivel | 30 |
| 1995 | Home for the HolidaysMovie | Tommy Larson | 30 |
| 1994 | Natural Born KillersMovie | Wayne Gale | 29 |
| 1994 | Only YouMovie | Peter Wright | 29 |
| 1993 | RawSeries | Self (archive footage) | 28 |
| 1993 | Short CutsMovie | Bill Bush | 28 |
| 1993 | Late Show with David LettermanSeries | Self - Guest | 28 |
| 1993 | Late Night with Conan O'BrienSeries | Self - Guest | 28 |
| 1993 | Heart and SoulsMovie | Thomas Reilly | 28 |
| 1992 | The Tonight Show with Jay LenoSeries | — | 27 |
| 1992 | ChaplinMovie | Charles Spencer Chaplin | 27 |
| 1991 | SoapdishMovie | David Seton Barnes | 26 |
| 1990 | Air AmericaMovie | Billy Covington | 25 |
| 1989 | Chances AreMovie | Alex Finch | 24 |
| 1989 | True BelieverMovie | Roger Baron | 24 |
| 1988 | LIVE with Kelly and MarkSeries | Self - Guest | 23 |
| 1988 | This MorningSeries | Self - Interviewee | 23 |
| 1988 | Johnny Be GoodMovie | Leo Wiggins | 23 |
| 1988 | 1969Movie | Ralph Carr | 23 |
| 1987 | The Pick-up ArtistMovie | Jack Jericho | 22 |
| 1987 | Kids' Choice AwardsSeries | Self | 22 |
| 1987 | Dear America: Letters Home from VietnamMovie | (voice) | 22 |
| 1987 | Less Than ZeroMovie | Julian | 22 |
| 1986 | American MastersSeries | Self | 21 |
| 1986 | AmericaMovie | Paulie Hackley | 21 |
| 1986 | Back to SchoolMovie | Derek | 21 |
| 1985 | Tuff TurfMovie | Jimmy Parker | 20 |
| 1985 | Weird ScienceMovie | Ian | 20 |
| 1985 | Girls Just Want to Have FunMovie | Punk Party Crasher (uncredited) | 20 |
| 1985 | Mussolini: The Untold StorySeries | Bruno Mussolini | 20 |
| 1984 | FirstbornMovie | Lee | 19 |
| 1983 | Baby It's YouMovie | Stewart | 18 |
| 1982 | Late Night with David LettermanSeries | Self - Guest | 17 |
| 1981 | Entertainment TonightSeries | Self | 16 |
| 1980 | Up the AcademyMovie | Boy on Soccer Team (uncredited) | 15 |
| 1975 | Saturday Night LiveSeries | Self - Various Characters | 10 |
| 1975 | People's Choice AwardsSeries | Self - Presenter | 10 |
| 1953 | The OscarsSeries | Self - Presenter | — |