| 2026 | Kill Tony: Once Upon a Time in TexasMovie | Self | 74 |
| 2024 | The Tucker Carlson ShowSeries | Self | 72 |
| 2021 | When Ruby Wax Met...Series | Self (archive footage) | 69 |
| 2018 | Fahrenheit 11/9Movie | Self | 66 |
| 2015 | Roseanne for President!Movie | Self | 63 |
| 2014 | Mystical Traveler: The Life and Times of Dr. John-RogerMovie | Self (archive footage) | 62 |
| 2014 | Baal Shem Tov: Master of a Good NameMovie | Grandma Ruth | 62 |
| 2013 | The MillersSeries | Darla | 61 |
| 2013 | Norm Macdonald LiveSeries | Self | 61 |
| 2012 | Teenage Mutant Ninja TurtlesSeries | Kraang Prime (voice) | 60 |
| 2012 | Comedy Central Roast of RoseanneMovie | Self | 60 |
| 2011 | PortlandiaSeries | Interim Mayor | 59 |
| 2011 | Looking for LennyMovie | Self | 59 |
| 2010 | I Am ComicMovie | Self | 58 |
| 2010 | ConanSeries | Self | 58 |
| 2008 | Big Brother: Celebrity HijackSeries | Herself - Hijacker | 56 |
| 2007 | Mr. Warmth: The Don Rickles ProjectMovie | Self | 55 |
| 2007 | Slacker UprisingMovie | Self | 55 |
| 2007 | Alexis Arquette: She's My BrotherMovie | Self | 55 |
| 2007 | Boulevard of Broken DreamsSeries | Self (archive footage) | 55 |
| 2005 | The OfficeSeries | Carla Fern | 53 |
| 2005 | My Name Is EarlSeries | Millie Banks | 53 |
| 2005 | The Reichen ShowSeries | Self | 53 |
| 2005 | Class Dismissed: How TV Frames the Working ClassMovie | Self (archive footage) | 53 |
| 2004 | Home on the RangeMovie | Maggie (voice) | 52 |
| 2004 | Goodnight, We Love YouMovie | Self | 52 |
| 2003 | Jimmy Kimmel Live!Series | Self | 51 |
| 2003 | The Ellen DeGeneres ShowSeries | Self | 51 |
| 2003 | ABC's 50th Anniversary CelebrationMovie | Self | 51 |
| 2003 | The Brothers Garcia: Mysteries of the MayaMovie | Co-pilot | 51 |
| 2003 | Real Time with Bill MaherSeries | Self | 51 |
| 2001 | 15 MinutesMovie | Roseanne | 49 |
| 2001 | Playboy Mansion Parties UncensoredMovie | Self | 49 |
| 2000 | The Eyes of Tammy FayeMovie | Self (archive footage) | 48 |
| 1999 | FuturamaSeries | Roseanne Barr (voice) | 47 |
| 1999 | Get Bruce!Movie | Self | 47 |
| 1999 | Dancing Outlaw II: Jesco Goes to HollywoodMovie | Herself | 47 |
| 1998 | Hollywood SquaresSeries | Self - Panelist | 46 |
| 1997 | The ViewSeries | Self | 45 |
| 1997 | Meet Wally SparksMovie | Roseanne Barr | 45 |
| 1997 | Happy Birthday Elizabeth: A Celebration of LifeMovie | Self | 45 |
| 1996 | 3rd Rock from the SunSeries | Janet | 44 |
| 1996 | Ruby Wax MeetsSeries | — | 44 |
| 1996 | Love in HollywoodMovie | Self | 44 |
| 1995 | Women of the HouseSeries | Self | 43 |
| 1995 | Blue in the FaceMovie | Dot | 43 |
| 1995 | Sinatra: 80 Years My WayMovie | Self - Presenter | 43 |
| 1994 | Inside the Actors StudioSeries | Self | 42 |
| 1994 | Even Cowgirls Get the BluesMovie | Madame Zoe | 42 |
| 1993 | The NannySeries | Sheila | 41 |
| 1993 | Late Show with David LettermanSeries | Self - Guest | 41 |
| 1993 | Politically IncorrectSeries | — | 41 |
| 1992 | The Larry Sanders ShowSeries | Roseanne Barr | 40 |
| 1992 | The Jackie Thomas ShowSeries | Roseanne Conner | 40 |
| 1992 | The Rosey & Buddy ShowMovie | Rosey (voice) | 40 |
| 1991 | Freddy's Dead: The Final NightmareMovie | Ethel | 39 |
| 1991 | Amnesty International's Big 30Movie | Self | 39 |
| 1990 | Look Who's Talking TooMovie | Julie (voice) | 38 |
| 1989 | She-DevilMovie | Ruth Patchett | 37 |
| 1989 | DecadeMovie | Self | 37 |
| 1988 | RoseanneSeries | Roseanne Conner | 36 |
| 1987 | A Different WorldSeries | Looter | 35 |
| 1986 | Rodney Dangerfield: It's Not Easy Bein' MeMovie | Self | 34 |
| 1975 | Saturday Night LiveSeries | Self - Host | 23 |
