Filmography66 titles
| Year | Title | Character | Age at release |
|---|---|---|---|
| 2026 | Yellow MirrorMovie | Lisa Simpson (voice) | 62 |
| 2026 | Extreme Makeover: Homer EditionMovie | Lisa Simpson (voice) | 62 |
| 2026 | SimpsleyMovie | Lisa (voice) | 62 |
| 2023 | Who Are You PeopleMovie | Sarah | 59 |
| 2022 | Inventions That Changed HistorySeries | Self - Comic Actress | 58 |
| 2022 | Welcome to the ClubMovie | Lisa Simpson (voice) | 58 |
| 2022 | The Simpsons Meet the Bocellis in "Feliz Navidad"Movie | Lisa Simpson (voice) | 58 |
| 2021 | The Simpsons in PlusaversaryMovie | Lisa Simpson (voice) | 57 |
| 2021 | The Good, the Bart, and the LokiMovie | Lisa Simpson (voice) | 57 |
| 2020 | Stars in the HouseSeries | Self | 56 |
| 2020 | Dear Class of 2020Movie | Lisa Simpson | 56 |
| 2015 | Fresh Off the BoatSeries | Marie | 51 |
| 2015 | TV's Funniest Animated Stars: A Paley Center for Media SpecialMovie | Self | 51 |
| 2013 | MomSeries | Enid | 49 |
| 2012 | The Mindy ProjectSeries | Dr. Carolyn King | 48 |
| 2012 | FOX 25th Anniversary SpecialMovie | Lisa Simpson (voice) (uncredited) | 48 |
| 2012 | 8Movie | Nancy F. Cott | 48 |
| 2011 | RevengeSeries | Phyllis | 47 |
| 2011 | New Year's EveMovie | Maude | 47 |
| 2011 | The ChaperoneMovie | Miss Miller | 47 |
| 2010 | Hot in ClevelandSeries | Margaret | 46 |
| 2010 | High SchoolMovie | Computer Skills Teacher | 46 |
| 2010 | The Simpsons 20th Anniversary Special - In 3D! On Ice!Movie | Self | 46 |
| 2007 | Mad MenSeries | Nurse Mary | 43 |
| 2007 | The Big Bang TheorySeries | Sandy | 43 |
| 2007 | The Simpsons MovieMovie | Lisa Simpson (voice) | 43 |
| 2005 | Back By MidnightMovie | Veronica | 41 |
| 2004 | Best Week EverSeries | — | 40 |
| 2004 | Phil of the FutureSeries | Mandy Teslow | 40 |
| 2003 | Dead Like MeSeries | Penny | 39 |
| 2000 | Strong MedicineSeries | Real Estate Agent | 36 |
| 2000 | The Simpsons: America's First FamilyMovie | Self | 36 |
| 2000 | CyberWorldMovie | Lisa Simpson (voice) | 36 |
| 1999 | Family GuySeries | Lisa Simpson (voice) | 35 |
| 1998 | BeckerSeries | Ruby | 34 |
| 1998 | Sports NightSeries | Malory Moss | 34 |
| 1997 | As Good as It GetsMovie | Jackie Simpson | 33 |
| 1997 | The Wonderful World of DisneySeries | Gatekeeper | 33 |
| 1997 | Smart GuySeries | Ms. Rawlings | 33 |
| 1997 | Dharma & GregSeries | Marlene | 33 |
| 1997 | Just WriteMovie | Lulu | 33 |
| 1997 | Teen AngelSeries | Miss Gross | 33 |
| 1996 | Nash BridgesSeries | Stevie Strong | 32 |
| 1996 | Jingle All the WayMovie | Woman Who Flirts with Howie (uncredited) | 32 |
| 1994 | Inside the Actors StudioSeries | Self | 30 |
| 1993 | We're Back! A Dinosaur's StoryMovie | Cecilia (voice) | 29 |
| 1993 | Sesame Street's 25th Birthday: A Musical CelebrationMovie | Lisa Simpson (voice) (segment "Monster in the Mirror") (uncredited) | 29 |
| 1992 | ToysMovie | Researcher | 28 |
| 1991 | Herman's HeadSeries | Louise Fitzer | 27 |
| 1991 | City SlickersMovie | Nancy | 27 |
| 1990 | SydneySeries | — | 26 |
| 1989 | The SimpsonsSeries | Lisa Simpson (voice) | 25 |
| 1989 | Listen to MeMovie | Cootz | 25 |
| 1989 | Silence Like GlassMovie | — | 25 |
| 1989 | Ginger Ale AfternoonMovie | Bonnie | 25 |
| 1988 | Murphy BrownSeries | Phoebe Cramer | 24 |
| 1987 | The Tracey Ullman ShowSeries | Lisa Simpson (voice) | 23 |
| 1987 | Three O'Clock HighMovie | Cheerleader | 23 |
| 1987 | MathnetSeries | Jane Rice Burroughs | 23 |
| 1987 | Square One TelevisionSeries | Jane Rice-Burroughs | 23 |
| 1986 | Maximum OverdriveMovie | Connie | 22 |
| 1985 | Heaven Help UsMovie | Cathleen | 21 |
| 1985 | The Legend of Billie JeanMovie | Putter | 21 |
| 1984 | Tales from the DarksideSeries | Betty Ann Cooper / Good Time Rita | 20 |
| 1984 | BrothersSeries | Louella Waters | 20 |
| 1972 | ABC Afterschool SpecialSeries | Jenny | 8 |